It has been fascinating in the last year to see the unfolding story of mutations in histone variant H3.3 in pediatric glioblastoma and related tumors. It seems amazing that in just over a year, a whole new area of cancer research has rapidly progressed. As I discussed in a recent post, histone H3.3 is a […]
Allis lab Science paper on histone H3.3 in pediatric brain cancer Read More »
St. Baldrick’s is the top children’s cancer foundation and does amazing work for kids with cancer and their families. Their top fundraising event is a head-shaving program where people make pledges in support of a “shavee” who gets their head shaved in solidarity with kids with cancer who often lose their hair due to treatment.
How baldness can cure kid’s cancer: St. Baldrick’s Foundation Read More »
What are the top action items for cancer stem cell field?Recently I spoke about cancer stem cells at a retreat. The presentation style was informal and enjoyable as it allowed for people to talk frankly about topics. It encouraged questions and outside-the-box thinking. As I was eating some yogurt at breakfast at the meeting awaiting
My ‘back of napkin” list of top action items for cancer stem cell field Read More »
Yesterday was my 3-year anniversary of surgery for prostate cancer. I’m doing great in long-term remission and hopeful it stays that way. You never know. Knock on wood. Over the years, as both a cancer researcher and patient, I’ve found myself frustrated with the way the media fails at reporting on supposed risky behaviors for
Media’s crazy cocktails on cancer: today’s case of whole milk and soda Read More »
Three years ago I found myself in a tough spot to put it mildly with a prostate cancer diagnosis at age 42. In October 2009 I had a mildly elevated PSA test result (see more on that below) leading to a prostate biopsy. At the end of that month I had just received the news
Thoughts on prostate cancer…3 years out Read More »
Why are most brain cancers so difficult to treat leaving the unfortunate patients who suffer from them in dire circumstances so often? The short answer is that we don’t know why. This lack of understanding is like a wall standing between the cures and us for these patients. We have to climb or knockdown this
Brain cancer: why histones including H3.3 are so important Read More »
I’m a fan of iPS cells, but my lab has been concerned about the similarities between induced pluripotency and cancer formation for many years. We just now published a paper that directly addressed the similarities of cancer and iPS cell transcriptomes. These are cause for concern and need to be faced as we contemplate clinical
iPS cells are similar to cancer cells paper, part 2: unsettled reviewers Read More »
My lab just published a somewhat provocative paper (still in unproofed form at this point) arguing that iPS cells are very similar in some ways to cancer cells. How did we get to that conclusion (discussed in this post today, part 1 of the story) and what’s the back story on this paper (discussed in a later
iPS cells are similar to cancer cells: part 1 of discussion of new paper Read More »
Yesterday I managed to get to see a fabulous talk by Dr. Edison Liu, President and CEO of The Jackson Laboratory in Maine. I was able to squeeze it in, in between working on my R01 proposal and preparing for teaching histo to the med students here at UC Davis Med School. Dr. Liu was