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250,000-fold oversight on 3-person IVF mitochondrial transfer?

June 23, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Remember the debate over so-called 3-person IVF? The goal of this technology, also referred to as mitochondrial transfer and 3-parent IVF, is to prevent mitochondrial disease through nuclear transfer in oocytes or one-cell embryos. The resulting genetically modified (GM) human embryos and ultimately children if it works could have dodged mitochondrial disease, but also could have serious or […]

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Americans relatively more comfortable with human cloning

June 2, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

What is morally acceptable and where do we draw the line at behaviors that might just go too far such as human reproductive cloning? Over the years American attitudes have shifted on a number of potentially hot button moral behaviors including reproductive human cloning and pollsters including Gallup have tracked these attitudes. Gallup just came out

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Public polling on human gene editing, moratorium

May 21, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Many of us scientists, ethicists, and legal scholars are working on educational outreach to the public on the potential use of gene editing technologies like CRISPR to genetically modify human beings, but clearly there’s a long way to go and much more to do on this front. By the way, you may find this new

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Stanford Human Germline Modification Meeting: Medicine, Science, Ethics, & Law

May 18, 2015 / Professor Paul Knoepfler, Ph.D.

Last Thursday I participated in a meeting at Stanford Law School on human germline genetic modification hosted by Hank Greely (pictured at left), Professor of Law and Genetics at Stanford. The meeting was entitled, “Human Germline Modification: Medicine, Science, Ethics, and Law”. The panel included in addition to Hank and me, the following speakers: Marcy Darnovsky, Executive Director of

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GMO: Why 3 Such Difficult Little Letters?

May 5, 2015 / Professor Paul Knoepfler, Ph.D. / 11 Comments

What is a GMO? I realized a few years ago that I really should know a lot more about the whole debate over genetically modified (GM) organisms (GMOs). What are the facts on GMOs? As a scientist who has for many years done amongst other things genetics research including making and studying so-called “knockout mice”

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Biotechnology & the Ethical Imagination – A Preview of BEINGS summit

May 4, 2015 / Aaron Levine

Later this May, I will attend and participate in Biotechnology and the Ethical Imagination (BEINGS 2015). This is an exciting and experimental summit that will focus on advances in cellular biotechnology – including both stem cell science and synthetic biology. The meeting is premised on the idea that the implications of increasing biotechnology power are

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News bites & rumors on human embryo genetic modification

April 30, 2015 / Professor Paul Knoepfler, Ph.D. / 8 Comments

A lot has happened in the week since the first human embryo genetic modification paper was published by a team led by Junjiu Huang. There have been a number of new events just in the last few days. Jocelyn Kaiser over at SCIENCEINSIDER has a new piece reporting a couple important developments including that the journal

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Concerns surface on Chinese paper on genetic modification of human embryos

April 25, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

The paper that came out Wednesday from a research group in China reporting the first genetic modification of human embryos has sparked a lot of discussion. Some concerns about this paper have surfaced. 2-day review? The paper (HT to John Borghi) was in review only from March 30-April 1 — so at most 48 hours. Really? That certainly

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Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease

April 23, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI)

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Researchers in China make genetically modified human embryos

April 22, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Rumors have been flying for months that researchers in China and possibly elsewhere were shopping papers around at high-profile journals that reported gene editing and genetic modification of human embryos. Update: apparently this paper (HT to @JohnBorghi) was only reviewed for 2 days (see image at bottom of post), raising major concerns about the depth of

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