Induced pluripotent stem cells or iPS cells just might be the most exciting development in the stem cell field over the last 15 years. They have unique potential for clinical impact for regenerative medicine too. This may manifest both through their use to produce differentiated cellular therapies and indirectly via disease modeling as well as […]
What are induced pluripotent stem cells or IPS cells? Read More »
This week we have some interesting new reading including both on the stem cell basic and translational fronts as well as on COVID-19 vaccines. COVID-19 vaccine considerations From Derek Lowe at In The Pipeline on COVID-19 vaccine expectations at Science Translational Medicine, Get Ready for False Side Effects. You can read my views on possible
Recommended stem cell reads: retractions, aging, COVID, CRISPR soldiers Read More »
It’s fitting, given the edginess over the election, that Halloween is falling only a few days before election day so here is a list of recommended stem cell reads for you to dive into some biomedical science. Liver buds from stem cells Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and
Stem cell reads: liver buds, MSCs, SMARC, more Read More »
When you sit down to read science on the weekends lately, assuming you are not primarily a COVID-19 researcher, how much COVID stuff seeps into your reading? As I was going over some of this year’s recommended weekly reads posts here on The Niche, I’ve realized that an increasing amount of COVID-19 research has joined
Recommended reads: PSC, COVID, FDA pledge, sci jobs Read More »
Introduction to CAR-T cells CAR-T cells are an exciting cutting-edge technology that has been garnering great interest including in the stem cell field. Potential therapeutic uses of CAR-T, which stands for Chimeric Antigen Receptor T-Cells (CAR-T), are being studied in clinical trials as immunotherapies to potentially fight cancer as well as many other diseases by
CAR-T cells review: cancer & a critical look at possible uses in aging & COVID-19 Read More »
Where do things stand today in 2020 with IPS cell research? It’s been 14 years since they were first reported, but they continue to make news. Back in 2006 I was wrapping up my postdoc with Bob Eisenman at The Hutch in Seattle, largely studying Myc, when Shinya Yamanaka published his first induced pluripotent stem
IPS cell field update: easy culture, Parkinson’s, scarring, immune cells, & mutations Read More »
A new Nature paper makes the striking claim that neural precursor cells of the brain migrate all the way to prostate tumors. Furthermore, the team led by Claire Magnon claims that these long-distance cellular travelers from the brain not only take up residence in the prostate but also strongly drive progression of the prostate cancer
Probing Nature pub’s puzzling claim of brain cells globetrotting into prostate tumors Read More »
There are many genomics meetings out there these days, but The Future of Genomic Medicine meeting (#FOGM18) at Scripps in La Jolla is one of my favorites. This meeting is uniquely empowering. The people and the talks combine for a one-of-a-kind experience. The venue doesn’t hurt either at the Scripps Seaside Forum. The evening before the meeting
Highlights #FOGM18 Day 1: Data from Ancient Dirt, Genomics Dilemmas, CAR-T, & CRISPR Read More »
I’ve been gardening since I was a kid and I guess I’ve been a scientist that long too so now it’s time for another installment of “scientist in the garden.” You can see past such posts here, which usually include various cool photos. Today’s post is focused on unusual things in the garden. Getting out
Scientist in the garden: purple cauliflower & other cool photos Read More »
Bulls-eye! Here are some stem cell weekend reads including both interesting new papers & news headlines. Of course, this week also had stem cell awareness day and I wrote about 10 key issues for the field for the coming 10 years! Weekend reads Papers Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during
TGIF stem cell weekend reads of papers & news Read More »