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Quick journal club on IPSC anti-aging paper: cool, but outstanding questions

December 15, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

A new Cell paper from Juan Carlos Izpisua Berlmonte’s group has made headlines about anti-aging across the globe because it suggests that the four core induced pluripotent stem cell (IPSC) factors use by Shinya Yamanaka to make IPSC can reverse aging. I’ve pasted the graphical abstract from the paper below and done a quick journal club style …

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5 thought-provoking new stem cell papers

August 21, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

One of the best things as a stem cell scientist is to see all the new stem cell papers that come out. Here are 5 thought provoking new ones. Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells (Nature) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation (Cell Stem …

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New NgAgo protocol: helpful or more of a red flag?

August 14, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

The supposed new gene editing technology NgAgo has had the scissors taken to it with basically no one able to get it to work conclusively and now the professor who led the work, Chunyu Han, has posted a new NgAgo protocol on the Addgene website. Updated NgAgo gene-editing: scientist posts revised protocol, with skeptical response …

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Knoepfler Lab 2015: Our mission and research

September 15, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

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Many of this blog’s readers ask about my own lab’s research: what is the focus of the work in the Knoepfler Lab? You can go check out our lab website, but I thought it might be time again to blog about what we are all about as a lab and what we have been up …

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Lessons from New IPS Cell Study Showing Tumors

February 17, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 11 Comments

A cool new paper is out in Stem Cell Reports describing long-term tumorigenicity of human induced pluripotent stem cells (IPSC or IPS cells). See graphical abstract. The potential tumorigenicity of IPSC is a major concern when teams around the world are translating IPSC technology to the bedside. Past studies including one from my own lab have …

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TGIF: Biomedical weekend reading includes some cool papers

January 23, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

TGIF: I’m working on an R01, but I still try to find time to read a wide variety of papers. Below are the science pubs that I’m hoping to get to this weekend. Less Myc, longer “health span” Cell paper from Sedivy Lab. ESC Histone H3.3 nucleosomal functions Epigenetics & Chromatin paper from Keji Zhao Lab. Human …

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Post-Publication Paper Reviews & Commentaries

2015 Review of Vogelstein “Bad Luck” Cancer & Stem Cell Paper in Science January 02, 2015 2014 What Does New Paper Mean for Future of Nuclear Transfer ES Cells? November 9, 2014 Encouraging New Paper on ACT Stem Cell-Based Trial for Macular Degeneration October 14, 2014 Top 10 Takeaways From Harvard Stem Cell Diabetes …

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About Us, The Niche and Knoepfler Lab

The Niche is the top, most authoritative stem cell and regenerative medicine blog on the web and the only one to our knowledge written by a professor. It is mainly written by Professor Paul Knoepfler of UC Davis School of Medicine, an internationally respected stem cell biologist and educator. Knoepfler is an advocate of rigorous …

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Knoepfler Lab: Our mission and research

July 29, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

Many of this The Niche‘s readers ask about what my own lab’s research. What is the focus of the research of the Knoepfler Lab? You can go check out our lab website, but I thought it might be time to blog about what we are all about as a lab and what we have been …

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Cool paper by Cowley Lab on the role of HDACs in ES cells

June 30, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

It was great being a postdoc in Bob Eisenman’s Lab at the Hutch in Seattle. I loved it. Bob is a great mentor (see more on my experience there here) and the scientific interactions in the lab were wonderful. It’s been fun and interesting to follow the work of my fellow former Eisenman lab members over the …

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