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Probing Nature pub’s puzzling claim of brain cells globetrotting into prostate tumors

May 19, 2019 / Professor Paul Knoepfler, Ph.D. / 8 Comments

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A new Nature paper makes the striking claim that neural precursor cells of the brain migrate all the way to prostate tumors. Furthermore, the team led by Claire Magnon claims that these long-distance cellular travelers from the brain not only take up residence in the prostate but also strongly drive progression of the prostate cancer […]

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Highlights FOGM18 Day 1: Data from Ancient Dirt, Genomics Dilemmas, CAR-T, CRISPR

March 2, 2018 / Professor Paul Knoepfler, Ph.D. / 2 Comments

There are many genomics meetings out there these days, but The Future of Genomic Medicine meeting (#FOGM18) at Scripps in La Jolla is one of my favorites. This meeting is uniquely empowering. The people and the talks combine for a one-of-a-kind experience. The venue doesn’t hurt either at the Scripps Seaside Forum. The evening before the meeting

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TGIF stem cell weekend reads of papers & news

October 13, 2017 / Professor Paul Knoepfler, Ph.D.

Bulls-eye! Here are some stem cell weekend reads including both interesting new papers & news headlines. Of course, this week also had stem cell awareness day and I wrote about 10 key issues for the field for the coming 10 years! Weekend reads Papers Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during

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7 cool new stem cell research papers

April 12, 2017 / Professor Paul Knoepfler, Ph.D. / 6 Comments

As a stem cell biologist it’s fun to read new papers on the latest cutting edge research. In that spirit, here is a list of 7 recent stem cell and regenerative medicine papers that caught my eye as particularly notable and that have sparked discussion. From PLoS Biology: Manipulating the Germinal Activity of the Brain From Nature

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~10th anniversary of my 1st website: reflecting on wild ride

January 30, 2017 / Professor Paul Knoepfler, Ph.D. / 3 Comments

It was just over a decade ago that I started making websites and it’s been a wild ride. My first site was at the domain name www.chromatin.com, which I was fortunate to have been able to get for a good deal way back when…I think in 2005. You can see here an early 2007 copy

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Quick journal club on IPSC anti-aging paper: cool, but outstanding questions

December 15, 2016 / Professor Paul Knoepfler, Ph.D. / 6 Comments

A new Cell paper from Juan Carlos Izpisua Berlmonte’s group has made headlines about anti-aging across the globe because it suggests that the four core induced pluripotent stem cell (IPSC) factors use by Shinya Yamanaka to make IPSC can reverse aging. I’ve pasted the graphical abstract from the paper below and done a quick journal club style

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5 thought-provoking new stem cell papers

August 21, 2016 / Professor Paul Knoepfler, Ph.D.

One of the best things as a stem cell scientist is to see all the new stem cell papers that come out. Here are 5 thought provoking new ones. Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells (Nature) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation (Cell Stem

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New NgAgo protocol: helpful or more of a red flag?

August 14, 2016 / Professor Paul Knoepfler, Ph.D.

The supposed new gene editing technology NgAgo has had the scissors taken to it with basically no one able to get it to work conclusively and now the professor who led the work, Chunyu Han, has posted a new NgAgo protocol on the Addgene website. Updated NgAgo gene-editing: scientist posts revised protocol, with skeptical response

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Knoepfler Lab 2015: Our mission and research

September 15, 2015 / Professor Paul Knoepfler, Ph.D.

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Many of this blog’s readers ask about my own lab’s research: what is the focus of the work in the Knoepfler Lab? You can go check out our lab website, but I thought it might be time again to blog about what we are all about as a lab and what we have been up

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Lessons from New IPS Cell Study Showing Tumors

February 17, 2015 / Professor Paul Knoepfler, Ph.D. / 11 Comments

A cool new paper is out in Stem Cell Reports describing long-term tumorigenicity of human induced pluripotent stem cells (IPSC or IPS cells). See graphical abstract. The potential tumorigenicity of IPSC is a major concern when teams around the world are translating IPSC technology to the bedside. Past studies including one from my own lab have

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