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Regenerative reads: brain organoids, Clinicaltrials.gov change

February 28, 2021 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Sometimes change takes a very long time, but with brain organoids or advocating for better information for patients at Clinicaltrials.gov, after waiting you can see some interesting developments. These are two of the regenerative medicine stories of the week, along with some striking research papers. Clinicaltrials.gov Some of us have been advocating for improvements at […]

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Dissecting that Neanderthal brain organoids Science pub

February 15, 2021 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Organoids and especially brain organoids, which are made from pluripotent stem cells, are one of the most interesting developmental biology technologies of the last half a dozen or so years. Still some folks can’t help but get carried away when thinking about brain organoids it seems. A new Science paper from a team led by

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Regenerative reads: pig fat, cancer, organoids, more

October 18, 2020 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Chen-et-al-STM-2020-7a-fat-stem-cells-bone-sm

It’s usually a tossup as to whether my weekly reads skew more towards stem cells/regenerative medicine or cancer. Other times they are more enriched for genomics and epigenetics articles. Seeds of cancer in normal skin, Nature News & Views Engineering synthetic morphogen systems that can program multicellular patterning, Science. Pig fat can be used to

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Weekly reads on organoids, COVID, CRISPR, cold chromatin, more

October 11, 2020 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

As a researcher, is there ever enough time to get to everything that you want to read especially in newer areas like stem cells, organoids, and CRISPR, without even including non-scientific reads like Shakespeare or a new novel or something like that? Hopefully, putting together lists of recommended reads like today’s post is helpful. I

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Weekly reads: organoids, COVID-19, CIRM & cool new pubs

June 28, 2020 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Human-intestinal-organoids-infected-with-SARS-CoV-2-white.-Credit-Joep-BeumerClevers-groupHubrecht-Institute

Organoids are providing a novel avenue into the pathogenesis of COVID-19 and novel models for drug screening. A number of new preprints on respiratory organoids shed new light in this area. They were highlighted in a Nature newsy piece, Mini organs reveal how the coronavirus ravages the body. It’s a challenge to study COVID-19 infections because just infecting

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Recent stem cell news: vision, brain organoids, & lab meat

September 2, 2019 / Professor Paul Knoepfler, Ph.D. / 1 Comment

365 days a year, 24 hours a day stem cells are growing in labs around the world, providing a never-ending stream of data and products, with real hope, good news, and lots of surprises. You can see some past examples of good news in the stem cell and regenerative medicine field highlighted on The Niche here.

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Digesting new esophageal organoids papers

September 25, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

There’s a new paper in Cell Stem Cell on esophageal organoids that has really caught people’s attention. It is entitled, “3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.” It comes from a team led by Jianwen Que. Update: I didn’t realize when I first did this post that

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Weekend reads: stem cells, organoids, cancer, CRISPR & a tiger named Igor

April 27, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

What are your typical weekend reads? If you are a scientist, they might often include a great deal of science. I always hope I can find time for reading for pleasure too, but about as close as I get to that is the New York Times on Sunday. Here are some recommended science reads for

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Stem cell good news for the holidays: biotechs, FDA, organoids

December 7, 2017 / Professor Paul Knoepfler, Ph.D.

Atsuhiro-Taguchi-and-Ryuichi-Nishinakamura-part-of-Figure-4-Cell-Stem-Cell-2017

I can see many reasons to be jolly on the regenerative medicine front as we get deeper into the holiday season as there is quite a lot of stem cell good news even if there is also some not so good news. In today’s post the focus is on the good news of late. Semma

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Cool stem cell papers: antibody reprogramming, organoids, gravity, & more

September 13, 2017 / Professor Paul Knoepfler, Ph.D.

The past few weeks have brought some exciting, thought-provoking stem cell papers and developments in the regenerative medicine field. Here’s a list of stem cell papers in the media that struck me as particularly cool along with some other developments in the field. Human Stem Cells Fight Parkinson’s Disease in Monkeys Organoids Reveal Clues to Gut-Brain

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