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Recap of BEINGS 2015 Meeting by Aaron Levine: Shaping Future of Cellular Biotech

May 29, 2015 / Aaron Levine

Last week I attended Biotech & the Ethical Imagination (BEINGS 2015), the summit I previewed on this blog back in early May. It many ways the summit lived up to its lofty ambitions. Steven Pinker kicked off the event by emphasizing the power and importance of biomedical research, noting that almost everyone is affected by […]

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Public polling on human gene editing, moratorium

May 21, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Many of us scientists, ethicists, and legal scholars are working on educational outreach to the public on the potential use of gene editing technologies like CRISPR to genetically modify human beings, but clearly there’s a long way to go and much more to do on this front. By the way, you may find this new

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Stanford Human Germline Modification Meeting: Medicine, Science, Ethics, & Law

May 18, 2015 / Professor Paul Knoepfler, Ph.D.

Last Thursday I participated in a meeting at Stanford Law School on human germline genetic modification hosted by Hank Greely (pictured at left), Professor of Law and Genetics at Stanford. The meeting was entitled, “Human Germline Modification: Medicine, Science, Ethics, and Law”. The panel included in addition to Hank and me, the following speakers: Marcy Darnovsky, Executive Director of

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Stem cells on Mother’s Day, clinical trials, and more

May 10, 2015 / Professor Paul Knoepfler, Ph.D.

One of the many interesting ways in which “stem cells” are named in different languages around the world is “mother cells”. For example, in Spanish, you can learn more about these “mother cells” here in ¿Qué son las células madre? On Mother’s Day it is worth thinking about where the stem cell field stands at this

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GMO: Why 3 Such Difficult Little Letters?

May 5, 2015 / Professor Paul Knoepfler, Ph.D. / 11 Comments

What is a GMO? I realized a few years ago that I really should know a lot more about the whole debate over genetically modified (GM) organisms (GMOs). What are the facts on GMOs? As a scientist who has for many years done amongst other things genetics research including making and studying so-called “knockout mice”

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David Brafman: Attending Stem Cell Clinic Infomercial

April 29, 2015 / Professor Paul Knoepfler, Ph.D. / 8 Comments

By David Brafman (from a stem cell clinic infomercial event). With the vast amount of information about stem cells available to the general public, many misconceptions exist regarding stem cells and their potential applications. Paul and other prominent stem cell scientists have done an excellent job of educating the public about the facts regarding stem

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The big blind spot on CRISPR for human embryo editing: PGD

April 24, 2015 / Professor Paul Knoepfler, Ph.D. / 10 Comments

There is a big old blind spot in the discussion over germline gene editing in humans: preimplantation genetic diagnosis (PGD). There’s been a lot of talk in 2015 about worries over how gene editing technology such as CRISPR might be used prematurely in the clinic in an unsafe or unethical manner in humans in the

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Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease

April 23, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI)

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Interview with Bioheart CSO, Kristin Comella including on FDA

April 21, 2015 / Professor Paul Knoepfler, Ph.D. / 13 Comments

I invited the Chief Scientific Officer (CSO) of Bioheart, Kristin Comella, to do an interview after hearing some buzz that this could be a critical time for the company and that it might have been recently visited by the FDA. Note that Comella not just Bioheart CSO, but also the primary instructor for physician training in stem

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