October 20, 2020

The Niche

Knoepfler lab stem cell blog

Obokata Can’t Reproduce STAP Cells

Obokata press conference

Signaling a nightmare ending to what was originally a fairy tale scientific story, the Japanese press (e.g. here) are reporting that Haruko Obokata has herself been unable to make STAP cells again as part of a RIKEN team testing STAP under watchful supervision.

In advance of a scheduled RIKEN press conference tomorrow, newspapers including Asahi Shimbun are reporting now that RIKEN will announce STAP was not replicated even with the involvement of Obokata.

Earlier this year RIKEN had said their internal investigation had found Obokata committed misconduct in her STAP research published in January as two papers in Nature that were later retracted.

Only three months ago, senior STAP paper author Charles Vacanti and collaborating scientist Koji Kojima of Brigham and Women’s Hospital reaffirmed their belief in STAP and posted a new STAP protocol on-line. They said STAP was a phenomenon in which “we have absolute confidence” and stressed the importance of adding ATP into the mix to make STAP, which had not been previously emphasized. It’s unknown if Obokata’s STAP replication efforts included trying the newer Vacanti protocol with ATP.

It’s unclear at this time what this somewhat final failed replication effort will mean for the STAP authors.

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