One of my main interests is the relationship between stem cells and cancer as well as what makes cancer stem cells tick. This week I’ve chosen to highlight articles on the role of stem cells in cancer plus other interesting publications.
Cancer pubs related to stem cells including on cancer stem cells
- Identification of cancer-related mutations in human pluripotent stem cells using RNA-seq analysis, Nature Protocols. In my own lab we’ve also been looking for oncogenes in pluripotent stem cells. In that effort we identified DPPA4 and DPPA2 as oncogenes. They’ve long been known as pluripotency-related factors, but from more recent data they appear to have important roles in specific cancers as well.
- Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis, G &D.
- Stem cells and origins of cancer in the upper gastrointestinal tract, Cell Stem Cell
- Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia, Cell Stem Cell.
Have you seen recent articles on cancer stem cells that you found to be particularly interesting?
Other notable recent pubs
- Single‐cell transcriptomic sequencing analyses of cell heterogeneity during osteogenesis of human adipose‐derived mesenchymal stem cells, Stem Cells
- Transient suppression of transplanted spermatogonial stem cell differentiation restores fertility in mice, Cell Stem Cell
- Pluripotent stem cell–derived corneal endothelial cells as an alternative to donor corneal endothelium in keratoplasty, Stem Cell Reports
- Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin, Dev. Cell.
- Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions, Nat Comm. What kind of organoids cannot be made?