What exactly is a mesenchymal cell and what does the acronym MSC stand for these days? I took a stab recently at discussing mesenchymal cells and the MSC acronym so check that out.
There is a great need for standards on MSCs and the products out there being marketed as MSCs are probably in reality dozens if not hundreds of different kinds of these cellular preparations. We’ll start the weekly reads with MSCs.
What is an MSC and how do we boost patient safety?
Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products, Stem Cells Translational Medicine. This comes from a team including the leader of our Stem Cell Program here at UC Davis, Professor Jan Nolta.
Check out my info page on MSCs/mesenchymal cells.
New authoritative cell and gene therapy site EuroGCT
Check out the new web resource on all things related to cellular and gene therapies.
I’m talking about the recently launched EuroGCT site. This resource is brought to you by the folks behind EuroStemCell.
More recommended reads
- I wrote last week about the exciting news of lasting remission or even a cure induced by CAR-T cells. Now we have a new paper that generates some hope for the main tumors my own lab is studying these days: diffuse midline gliomas with K27M mutations. GD2-CAR T cell therapy for H3K27M-mutated diffuse midline glioma, Nature. Great work from Michelle Monje’s lab. My lab is working on the more basic mechanisms of the H3.3 mutant gliomas as well as drug screening. You can read more about our work in the Knoepfler Lab.
- p53 directs leader cell behavior, migration, and clearance during epithelial repair, Science.
- A decade of molecular cell atlases, Lior Pachter’s blog. Lior doesn’t pull any punches on his site.
- Coupling comprehensive pesticide-wide association study to iPSC dopaminergic screening identifies and classifies Parkinson-relevant pesticides, preprint.