August 12, 2020

The Niche

Knoepfler lab stem cell blog

Search Results for: reprogramming

1 min read

What new papers and news in the stem cell sphere caught your eye? Here are some recent items that seem notable to me. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. This paper reports cellular reprogramming to insulin-producing cells in mice. They reprogrammed α-cells with Pdx1 and MafA proteins. ‘Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease’ in Nature Neuroscience. Using IPS cells for insights. “What open chromatin features predict pluripotency?” asked and answered by the authors of this review …Read More

1 min read

The past few weeks have brought some exciting, thought-provoking stem cell papers and developments in the regenerative medicine field. Here’s a list of stem cell papers in the media that struck me as particularly cool along with some other developments in the field. Human Stem Cells Fight Parkinson’s Disease in Monkeys Organoids Reveal Clues to Gut-Brain Communication (see image) Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor Health Canada investigates Canadian stem cell clinics Stem cells: Japan’s scientific ‘moonshot’ – Financial …Read More

3 min read

The second day of ISSCR 2016 started off with a great session on pluripotency and plasticity, and the first talk was by Shinya Yamanaka. He changed the title of his talk to “Reprogramming of Cells and Scientist”. As with my other posts on this meeting, this one is a stream of quotes and impressions from the talk. The beginning was more autobiographical on his part and then the second half was on basic science. I really enjoyed this talk overall. It’s now been a …Read More

3 min read

There’s some big, positive news on the stem cell front today. Two new innovative papers both by teams led by Sheng Ding of Gladstone Institutes with UCSF report all-chemical direct reprogramming of human somatic cells. Ding’s team took skin cells and by exposing them to cocktails of small molecules was able to turn them directly into precursors for heart muscle and neural cells. The two direct reprogramming papers were published in Science here and in Cell Stem Cell here. The former paper is Cao, et al. and the latter is Zhang, …Read More