Is 2022 going to be any better than 2020 or 2021 when it comes to things in general or for biomedical science? Related to the pandemic? It’s too soon to say but if I had to guess right now I’d venture an optimistic view that overall it’s going to be somewhat better by the end […]
Weekly science reads: senescence, alt CRISPR, sickle cell update Read More »
The world of stem cell research and regenerative medicine is unpredictable but it’s fun to be a part of it and try to do predictions. Each year in late December or early January I make prognostications for the coming year for stem cell research and regenerative medicine. I made 21 such predictions for the current
Grading my 21 stem cell & regenerative medicine predictions for 2021 Read More »
A type of human cells used in research called HEK cells or 293s has been much in the news lately. This is mainly related to COVID-19 vaccine research. There seem to be many misunderstandings about 293 cells. For that reason, I thought I’d do this post to clear things up. I’ve been working with these
Explainer on 293 or HEK cells and their use in COVID vaccine research Read More »
I’d say the paper of the week is on how PRC2 mediated H3K27me3 can in some sense replace elements of DNA methylation to repress. Very cool. Here it is: Sex-specific chromatin remodelling safeguards transcription in germ cells, Nature. Weird stuff In a merger of opposites, City of Hope to buy Cancer Treatment Centers of America
Weekly reads: PRC2, 2 weird bits of news, pubs, COVID stem cell hype Read More »
Part of being a grad student is dealing with technologies related to your projects and their limitations. Sometimes I feel old when I remember the way we used to have to do things in the lab. As a grad student, I manually poured, ran, and read giant sequencing gels. Back then, gene synthesis of a
Weekly reads: grad student life, cell barcoding, diabetes trial, more Read More »
Great ideas and talented scientists are not enough as biomedical research needs funding and here in the U.S. that means having R01 grant success. The trends since 1995 are slowly heading the wrong way. The average age of getting your first R01 grant keeps getting older. There is also still a bit of a possible
Weekly reads: R01 grant trends, DPPA4, adult human neurogenesis debate Read More »
The other day I was talking with some folks about stem cell policy on Zoom, which was great, but one phrase from them jumped out at me and gave me a laugh. “Joe Rogan is the Gwyneth Paltrow for bros.” It also just rings true to me. Some readers of The Niche may remember that
Weekly reads: Joe Rogan, stem cell, diet, clinics, more Read More »
Last week we lost Meri Firpo, a great scientist and dear friend in the stem cell community who touched many lives in positive ways. Today’s post is a tribute to Meri, who passed away from breast cancer. If you want to add a tribute please add a comment. Meri Firpo short bio Meri received her
Tribute to pioneering stem cell scientist Meri Firpo Read More »
The stem cell field lost a great scientist and friend this week with the passing of Meri Firpo from metastatic breast cancer. I’m going to post a tribute to Meri from several of us sometime this coming week. I’m in a bit of a somber mood but still trying to write, read, and do all
Weekly stem cell reads: COVID, tail regeneration, aging Read More »
This week marked the release of new draft FDA guidance on cell and gene therapies. Is the FDA kind of like the guidance counselor at school or more like the principal? It probably depends on many factors. I also find it funny how pretty much everyone in academia and biotech industry works to be compliant
Weekly reads: New FDA guidance, brains, MSCs, senescence Read More »