I’d say the paper of the week is on how PRC2 mediated H3K27me3 can in some sense replace elements of DNA methylation to repress. Very cool.
Here it is: Sex-specific chromatin remodelling safeguards transcription in germ cells, Nature.
In a merger of opposites, City of Hope to buy Cancer Treatment Centers of America for $390 million, STAT News. This doesn’t exactly seem like a great match. Will it be good for cancer patients? As a cancer survivor myself I wonder about corporate approaches to oncology.
Just got email telling me "IDseq is now named Chan Zuckerberg ID (CZ ID)"
— Jonathan Eisen (@phylogenomics) December 7, 2021
CZI Imposes a Vanity Sequence ID, The Geyser. Also, see the tweet from my colleague Jonathan Eisen above on this weird renaming of a genomic method. This move by Chan Zuckerberg gets a yuck rating from me. What’s next? Renaming ChIP-Seq to something like Lays-Seq after the potato chip brand?
More recommended reads including another PRC2 paper
It’s time to incorporate diversity into our basic science and disease models, Nature Cell Bio. From Rick Horowitz of the Allen Institute for Cell Science.
This Robot Looks Like a Pancake and Jumps Like a Maggot, NYT. Kind of brought xenobots to mind again, which I recently covered.
Autism and the Microbiome: The Wrong Way Around? In The Pipeline by Derek Lowe. This is a very interesting take on the hot area of autism and the gut microbiome. Derek raises the idea that the data may be pointing to autism-related behaviors influencing the microbiome, not vice versa as most people seem to assume.