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Stem cell good news: novel cancer work, new CA bills, Alzheimer’s, & more pubs

April 8, 2019 / Professor Paul Knoepfler, Ph.D. / 1 Comment

There’s nothing like stem cell good news and interesting publications to perk one up on a Monday. Enjoy. What recent papers have struck you as exciting? Novel stem cell-based cancer approaches (Part 1) It was exciting when Fate Therapeutics got the first induced pluripotent stem cell (IPSC) IND in the U.S. for their IPSC-derived natural killer cell […]

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4 possible roles for stem cell therapy besides cell replacement

February 6, 2019 / Professor Paul Knoepfler, Ph.D. / 20 Comments

Historically, the main route of proposed healing via stem cell therapy was cell replacement. In this way of thinking the transplanted cells engrafted (took up home) in the patient’s tissue and replaced dead or diseased cells. However, interest continues to grow in other possible modes of healing by stem cells that don’t rely on cell

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20 stem cell & regenerative medicine predictions for 2019

January 2, 2019 / Professor Paul Knoepfler, Ph.D. / 6 Comments

For a long time at the end of each year, I’ve been making stem cell predictions for the coming year. Most often I’ve been making a “top 20” list of predictions and today’s post has my list for 2019. You can see how I did for 2018 here, which might have been my best year

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Good final grades on my 20 x 2018 stem cell predictions

December 26, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Each year I make a list of stem cell predictions for the following year and I’ll release my predictions for 2019 soon, but first I’m grading how my 20 predictions for 2018 turned out. It seems I did better than usual predicting what would happen this year. I only got a couple partial credit or

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Context for my Nature piece on redefining “gene edit” to be more precise

December 19, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

When I say “gene edit” or “genome editing”, what’s the first thing that pops in your mind? It will depend on who you are. For many lay people until a few weeks ago when the world heard about He Jiankui‘s claim of CRISPR’d babies they may not have had anything pop in their heads when

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E. coli & more: digging into unique new stem cell clinic lawsuit

December 6, 2018 / Professor Paul Knoepfler, Ph.D. / 3 Comments

E. coli is a type of bacteria that can cause diseases such as serious GI illness if it ends up in the wrong place like in your food. You can spend the night in the bathroom or end up in the hospital or more rarely a grave depending on the subtype of E. coli. Some

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He Jiankui didn’t really gene edit those girls; he mutated them

December 4, 2018 / Professor Paul Knoepfler, Ph.D. / 10 Comments

Did Chinese researcher He Jiankui really CRISPR gene edit the CCR5 gene in two embryos producing twin baby girls? In my opinion the answer is “no”, but probably not for the reason you might think at first. He proclaims gene edits He claimed he had made twin baby girls with “gene edits”, which I feel is unethical

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Stem cell news bites: Astellas trial, cystic fibrosis claim, a few cool papers

August 7, 2018 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Stem cell news is always burbling up, sometimes right there in front of us on the web and other times via networks of people. Astellas news. Some may remember there used to be this pioneering stem cell biotech called ACT, which then became Ocata, and finally was acquired by the big company Astellas. One of

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Mixed Nuffield Council Report Too Aspirational on Human Genetic Modification

July 19, 2018 / Professor Paul Knoepfler, Ph.D. / 2 Comments

It’s an odd confluence of events this week that (A) the Nuffield Council, an ethics think tank, gives a thumbs up in a new report to heritable human genetic modification that would probably include using CRISPR in the same week that (B) a new paper reports that CRISPR can cause unpredictable genomic damage and several other concerning reports

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