September 26, 2020

The Niche

Knoepfler lab stem cell blog

Stem cell good news & pubs in late May 2019

The exciting and sometimes downright crazy giant stem cell ecosystem of legit research and unproven stem cell clinics could use a dose of good news now and then. In today post, I highlight some upbeat news and some interesting recent pubs.

Enjoy!

Sangeetha Vadakke-Madathil, et al. screenshot of video, PNAS 2019
Sangeetha Vadakke-Madathil, et al. screenshot of video, PNAS 2019.

From a team led by Hina Chaudhry, MD, Director of Cardiovascular Regenerative Medicine at the Icahn School of Medicine at Mt. Sinai, a new PNAS pub, “Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart.” Congrats to first author Sangeetha Vadakke-MadathilThis is a mouse study, but it has some translational potential for human patients. It also includes cool videos (you can see a screenshot of one at right.)

I need to read the paper before I can say how fully convinced I am of the central idea, but it’s on my reading list. For instance, I saw that in one figure they say they ruled out cell fusion in at least one context, but fusion is always a potential complicating factor with stem cell transplantation studies. For instance, in a hESC and hIPSC transplantation study my lab did with our colleague Veronica Martinez-Cerdeno, we found extension fusion of these stem cells with mouse brain cells. Again I need to dig into the pub in the coming week or two. Looks cool.

Single-cell proteomics! Wow from Cell Stem Cell. Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.

Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination. Another Cell Stem Cell piece, this one from a Matthew Porteus-led team.

Pluripotency or differentiation? That is the question. Here’s the original Molecular Cell paper from a team led by Micha Drukker, which has some insights into paraspeckles. You can learn more about paraspeckles here. In part, this paper (Modic, et al.), shows that NEAT1_2 Recruits TDP-43 into Paraspeckles. Congrats to first author Miha Modic.

Stem cell differences could explain why women are more likely to develop adrenal cancer.

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