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Weekly reads: R01 grant trends, DPPA4, adult human neurogenesis debate

November 21, 2021 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Great ideas and talented scientists are not enough as biomedical research needs funding and here in the U.S. that means having R01 grant success. The trends since 1995 are slowly heading the wrong way. The average age of getting your first R01 grant keeps getting older. There is also still a bit of a possible

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The Niche weekend reads: Editas mess, The Niche updates, papers

October 3, 2021 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

The news of the week relates to an interim clinical trial report from gene-editing firm Editas on its CRISPR trial for a form of vision loss. On to that in a minute. What have you been reading the past week? Below, I include our weekly list of recommended reads. However, first I wanted to give

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Weekly reads: vision, MyoD, liver regen, more

September 5, 2021 / Professor Paul Knoepfler, Ph.D. / 2 Comments

fish-eyes-from-stem-cells, stem cells for vision

I love stem cell research but experiments that have practical possible future applications in medicine like for vision loss are especially interesting to me. On the other hand basic research on core transcription factor mechanisms like by MyoD also really grab me. We cover some of this stuff and other ground in today’s recommended reads.

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When does a human embryo model become the real thing & other tough questions for a new field

May 19, 2021 / Professor Paul Knoepfler, Ph.D. / 2 Comments

A human embryo model is a laboratory-produced collection of living cells that has some key things in common with real human embryos. They are made from pluripotent stem cells, which include embryonic stem cells and induced pluripotent stem cells or iPS cells. This research is both exciting and ethically complicated, raising some difficult questions. Embryo

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New lab-grown blastoids are strikingly similar to human embryos

March 17, 2021 / Ricki Lewis / 2 Comments

A new word has been added to the lexicon of human stem cell research – blastoids, aka “blastocyst-like structures.” Unlike the familiar three-layered embryo that emerges during the third week of prenatal development, the earlier blastocyst resembles a fluid-filled soccer ball, with a smear of cells on the interior face destined to develop into the

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Weekly The Niche reads: lab-grown embryos & thymus, more

December 13, 2020 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Today’s The Niche recommended weekly reads post includes both primary papers and also a few media pieces. I’m especially interested in the first piece on making more complex embryo-like structures from ES cells. This is a long way from just making embryoid bodies or EBs. At the end of the post I discuss an article

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Regenerative reads: pig fat, cancer, organoids, more

October 18, 2020 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Chen-et-al-STM-2020-7a-fat-stem-cells-bone-sm

It’s usually a tossup as to whether my weekly reads skew more towards stem cells/regenerative medicine or cancer. Other times they are more enriched for genomics and epigenetics articles. Seeds of cancer in normal skin, Nature News & Views Engineering synthetic morphogen systems that can program multicellular patterning, Science. Pig fat can be used to

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Recommended reads: engineered niche, ALS, SCOTS trial, human genome “done”