If you’ve had a stem cell treatment, how was your experience?

stem cell treatments

Have you had a stem cell treatment and if so, what was your experience like?

I really value the diversity of readers on this blog from all over the world. I know we have a lot of readers who are patients and have had stem cell treatments. Every week I get emails from people asking about stem cell treatments and clinics.

I encourage you to weigh in here in the comments if you or a loved have had a stem cell treatment. What was it like? If it was positive, why did you feel that way? Same if it was negative.

How much did you have to pay and did you think it was reasonable?

What condition were you hoping to improve?

How did you find out about the clinic and would you refer someone else to them?

Anything else you’d like to share? Feel free to remain anonymous if you prefer.

199 thoughts on “If you’ve had a stem cell treatment, how was your experience?


  1. Yes, I had stem cell treatment in Tampa, Florida, my experience was negative in that it, or the following meds that I was “required” to take made me very ill.
    I paid over $10,000.00 and no I thought it an unreasonable price.
    The stem cell treatment was for C.O.P.D..
    My husband first saw a billboard on the highway when they first opened
    and because of the lack of results I would not recommend the clinic.
    The clinic and the people were very nice but of course I was paying them handsomely and after the failure of the first treatment they wanted me to have a different stem cell treatment at almost twice the price of the first one.


      • With the blood is prp. Unless you took terrible drugs first which forced the stem cells into your blood stream. At the cost you paid, I can pretty much assure you it was platelet rich plasma. Were you inhaling a mist or getting it IV?
        Katherine Knoll


      • Hi James more info wood be good, where did you have it why did you have it, how was it harvested…what is the name for this type of stem cell treatment ect


    • Hi Donna – I’m a TV Producer working on a piece about stem cell treatments and I’d love to speak with you. Please call me anytime at 212-259-1529. Thanks!!


      • Hello Lauren, my sister has ALS and I have been looking online for information on stem cell treatment for her. What does your piece focus on?


      • Hi Lauren, I am considering this procedure for hip OA. When/where will your piece air?
        Thanks
        Teresa Kinter (MI)


        • Hello Teresa, I am considering for my hip as well. If you get any information, please pass it on


        • Thinking about stem cells for my hip. Please pass on any info. Thank you


          • I had stem cell ,
            Prp and amniotic fluid injections in both my hips on Thursday 3/9/17
            I’m experiencing numbness in the right leg which I believe is the leg he took the stem cells from .
            Anyone have this issue ? If so did it go away and how long ?


            • I had PRP injections (January 2017) in my lower back. 3 months later and there’s no relief. No numbness, but tingling in my left foot. The injections were concentrated on the left side of my back. One injection hit a nerve going down my left leg and felt like a mild lighting bolt!) If I stretch it generally gets better. I was hoping for better news.


        • I had it 4 weeks ago it never stops hurting and the paperwork they gave me said it could hurt from 4 to6 mo. Or maybe will not get better at all. Please don’t do it .We should All take them to be shurt down .IT Don’t Work. Please don’t Do It. Lorene


      • Approximately 2 weeks ago, I had a placenta matrix injected into my tendons. Prior to this I had 2 surgeries. I had 8 years on my peroneal tendons. After the first 2 surgeries, I ruptured the tendons again, so my Podiatrist suggested the placenta matrix. I had never heard of it before. My insurance did not cover it, so I did have to pay for the (placenta) out of pocket, but not the procedure. It has been 2 weeks and I am still trying to heal. I pray that this works.


        • How are you doing now? I hope you are feeling better! I have a ruptured ankle tendon and am considering stem cells


      • This is a timely piece. The claims are so encouraging even to the point of replacing THipR . But I am 9 weeks into t he process for sever hip pain in Kansas City with no results. The hardest part for me was staying completely of Nsaids and Ibuprofen..Maybe I can call you as well.


      • Hi Donna my son is going to Mexico for stem cell treatment for M S. His appointment is in June. We have been doing events to save money for this. We live in Scotland.


        • Actually I had amniotic stem cell injection in my hip (osteoarthritis) went 9 weeks without ibuprofen, ice or any other anti inflammatory medication. No results – actually more hip pain. The chiropractic health center initially in the seminar and evaluation said that in the rare event that there was no improvement, they would re-administer the injection. Now they a re reneging and claim there is microscopic cartilage growth shown on an ex-ray. I am thinking of taking them to small claims court. I paid $3100.00 cash for the injection from a nurse practitioner in the office. I am 64 and have a high deductible health insurance plan til I’m 65.
          Jan


        • I have MS and talking with clinics in MX and StemGenex in California hope you’ve done your research. Each clinic has different approach and none seem to have any way to scientific test success/fail. ALSO, even if successful, must go back for booster treatments. Im still deciding and raising money in case I decide affirmative.


      • Hi Lauren, I just left u a phone msg. I’m starting to gather information to have stem cells with my platelets added to help with my oa and torn meniscus. Will it work for me? What type is recommended? The doc who would administer is an anesthesiologist. Thank you! Crossing fingers this is a good idea. I sure don’t want knee replacement.


      • Thinking about stem cell treatment for my hip. I am 74 years young, Dr. is recommending AMNIOTIC STEM CELLS Stated at my age cells are not as good and have fewer, therefore may be hard to harvest enough. Looking for any and all info on this from anyone and everyone.


    • I had a stem cell procedure on my lower back, a little under a month ago. I was told that I could go back to work the next day I am glad that I had the procedure just prior to a four-day weekend because I could barely move the next day. Even now, four weeks out, I am experiencing pain in my glutes, thighs and even feet.

      I understand it takes some time to heal. And I made the right decision to try this before yet another surgery. But I wish my Dr had just been honest that not everyone is “just sore for a few days.” Just to give an idea of how much it hurt: I had been prescribed Norco to take as needed, which I took daily – usually before I went to bed. But the post-stem cell procedure hurt so bad that she prescribed me an extended release morphine.

      Is this normal?


      • Hi I am a 48 year old male that had stem cell injection in my right hip. I also had an injection of Prp in my performas muscle. I had it done in mid November. I now have experienced severe shaking in my legs and sometimes upper body. I am definitely worse than before this procedure. I believe my vital nerve was hit during the procedures. I’m 3 months post surgery and sometimes in extreme pain in my leg and groin. The pain at the base of my Heal has minimized .


        • I had signs of AVN. Very minor considered a 1 on the scale of disease progression. So this was a preemptive strike at my femur head where it was visible on MRI. I will be getting another MRI in a week I will post results good or bad.


          • Steve, I would like to ask a favor. Please provide a definition for acronyms used. The same acronym can mean different things to different people. For example “MMP”. To some MMP means metal-metalo proteinases (enzymes that degrade tissue). To others, MMP means muscle morphogenetic protein (an inductive factor for skeletal muscle). Without a program one cannot figure out the players.

            Also, what is a “vital” nerve. I am no expert, but I don’t believe I have seen or heard that terminology before. The big nerves in the hip and leg are the sciatic nerve, femoral nerve, and obturator nerve? Which one(s) are you referring to?


            • A vital nerve . I don’t know which one I’m seeing many Doctors to try and figure it out. My heel feels like I have been hit with a sledge hammer. The pain intensifies at the right stem cell harvest point . It begins to burn like the needle is being pushed in the harvest location and starts to make my legs shake and groin pain. These symptoms can last anywhere from 20 minutes to 1 hour.
              I’m unable to work due to the severe leg shakes. Sciatica? What could have went wrong in my stem cell injections?


              • Dear Steve,
                Thank you for your definitions.
                Where exactly did they stick you with the needle?
                Sciatic nerve is located along your back side down to the knee; femoral nerve is located on front of thigh down to knee; and obturator nerve covers groin area and middle thigh down to knee.


      • I have read blogs from people who say it hurts like having a discogram (which I have not had). When I had the procedure done on my hips I was told the same thing but I had discomfort for 2 months. I did not need pain medication though so I would wonder if something else is going on. Any chance you have insurance to visit a physician and possibly get an MRI ?


    • hi. i just had a stem-cell infusion due to stage 4 chronic kidney disease. i will never go on dialysis, and there are no meds for CKD, so i figured why not? i live in florida at had this infusion in Largo. i also have been HIV for 37 years, however my immune system is aok. being dialysis not an answer for me, i decided to do the infusion….it cost me just 3K. do you mind if i ask why you did stem-cells?


      • doretta, you said, “…so i figured why not?” But aren’t you worried about infection? CKD is very prone to infections and mesenchymal stromal (stem) cells are powerful immune suppressors. In the clinic where I work here in Germany, the clinicians decided this was too dangerous for late-stage CKD patients. Anyway, wish you good luck and please let us know how it goes.


  2. The last treatment I had was part of a study. I paid nothing to participate. Stem cell therapy has been life changing for me. I was couch bound and was prone to getting bronchitis and pneumonia frequently before having stem cell treatment. I also was taking several prescription medications prior to treatment and now I only take one. I have COPD. I would gladly refer others to the doctor who treated me but he is no longer treating COPD patients because of the FDA.


    • What type of stem cell therapy was used? It is ashame when the FDA stands in the way of treatment of a dIsease like COPD.


    • I would love to hear more on this, I have COPD and and seriously thinking if this would be an option for me.


    • I am curious also , about the COPD treatments. Like….what type of stem cells did you use? Was PRP involved? How many times did you have to do it? Was it an IV drip, or were the stem cells injected? Were there any side effects? Like….was your breathing worse before it got better? Did you get congested for a while? I have read great things about this in the FDA studies , but they are SOOOOOO slowwwwww. It took 3 years for a preliminary study :/ And they go , what? 3 phases? Thats like 10 more years!! How many people will die , horrible, agonizing deaths before then? Stem cell therapy research has been around for decades , why is it just now coming out? Would love to hear more , and hope everyone here has great success with their treatments . It IS expensive , and not covered by insurance . Which…well I can go on forever about that!


  3. I traveled to Sunrise Florida in January to the US stem cell clinic and had the adipose tissue lipo’d from my left flank. The treatment lasted ~ an hour and 1/2 – the cost is generally $5000 with a 2000 extra (optional) cost for banking cells to take home. I was able to secure a spot for half price allowing students to train on me. Cost $2500. I also received 10 syringes with Platelet rich plasma to take home and use every 4th day. It made me congested and was uncomfortable for a day or two after using the PRP in a nebulizer.
    Its hard to quantify any increase in lung function but this can be used as an adjunct to diet and exercise and the proper supplements. I would recommend that those who do opt for the treatment, temper expectations but also realize strict diet and exercise is just as important or more important. I definitely feel it has helped if only to put me back to a rough baseline or at the very least, psychologically.


    • Hi Jim- I’m having treatment at this clinic in the next week for an autoimmune condition(fat extraction followed by IV treatment.) I am having second thoughts because I have read about the lawsuits filed against the clinic. I haven’t talked to any patients who have been there and there aren’t any reviews online. It sounds like you had a good experience. Could I contact you by personal email?
      Thanks- Phyllis


  4. Donna – above in her comment, stated the second treatment option offered by her clinic. – I believe she may be referring to cells that are derived from bone marrow and the cost ( at least for me is prohibitive) at $12,000.


      • So let us talk talk talk, but not name any clinics, eh? Are YOU one of the corrupt doctors or a clinic investor???


      • I’m with the “citizen!” How can you have a discussion without mentioning where you had your treatment done at? Like “citizen” said, are you one of the doctors or investors???!!!??


  5. On the 31/1/2009, I unfortunately had an anterior STEMI (heart attack) complicated by two VF arrest early in the post-infarct period, from which I was successfully resuscitated. My CK levels were recorded as 1479, although this will be influenced by the DC shocks. I was told after that it was a large infarct and made worse because there were no thrombolytic drugs available in Vanuatu where I lived. The doctor who looked after me was a miracle worker and he was on the telephone for hours to a specialist in New Zealand discussing what they could do and use to manage my problem. I survived as you can see but it took me some time to repair mentally and even today when I get ill it tends to play on your mind.

    Since then I have had 2 Adipose Derived Stem Cell (ADSC) treatments via IV in New Zealand. First in April 2012 costs NZ$8,000 and another in March 2014 costing NZ$4,000. My heart and kidney function improved by about 10-15% after the first treatment but slightly less after the second treatment. I am moving to New Zealand next month and in the process of arranging another stem cell treatment. The treatment is basically painless and it only takes a few hours and a day off work and driving. You just need to take it easy and wear a pressure girdle for about 10 days.

    I would just like to make a comment. I believe the treatment overall was cheap as I had a stent put in as the specialists hoped it may help my condition but after a visit some months later to check outcome they said it had not made any difference and was necessary. Not saying I would not have had it done if I had to choose but it did cost in total about NZ$30,000. Any medical treatment cost money and none can offer a 100% guaranteed outcome.

    After the first treatment I felt much better and was able to do almost all that I could do before my heart attack. This lasted for 12 to 18 months but I then notice that I was slowly losing energy and motivation to do things that is why I had another treatment. I fully understand and accept this is NOT a fix all but it has improved my life in general however I know that over time my health will deteriorate more so than normal people.
    My primary aim now, if I can stay well enough, is to find a hospital or clinic that is able to provide heart stem cell treatment using a mixture of bone marrow cells and cardiac cells grown from a heart biopsy to be injected back into the heart. I believe this will be an advance on the treatments I am currently having. I know the Texas Heart Institute is currently doing this but the cost for me and the chance of getting a placebo was not a workable option. I’m aware some doctors and researchers are using iPS cells, umbilical cord tissue cells or donors own blood cells however I have not followed up on any of these treatments.
    I am happy to discuss my venture and I’d like to make a point that what works for some will not work for others. Yes there are rogue clinics out there just to make money but there are also honest clinics, so do plenty of research and if possible talk to people who have had treatments for what you are seeking.


    • Yeah so how do we avoid the rogue clinics and find the good ones if we can’t mention clinic names!! Anyone know where to obtain such information OR know where I can get on a list to be included in a study. I need stem cell for my knees due to the crippling arthritis and can’t afford the $5k per knee I was quoted by a local clinic! Also how can I find out if this local clinic has a good reputation? Any help would be greatly appreciated!


      • I found this site while working on some marketing projects for the orthopedic office I work for, and although this post is from 3 months ago I wanted to offer a little info. We started doing the AlloGen injections a few months ago with great results so far. It is surprising to me, after researching the costs at other clinics, how much these injections are being marked up. I guess I am lucky to work for 2 orthopedic surgeons who are truly in this field to help people in our community, as they are charging less than half of what I have found to be the “normal” or average cost: we charge $2000 per injection, while the other clinics in our region average $4500-$6000 per injection. As one of the only clinics here in the eastern Michigan area who offer this treatment, we certainly could follow suit and take advantage of people who don’t want to travel the 2 hour drive to the Detroit area. We have patients who have called the injections “life-changing”, and I know that our physicians get more from hearing that then they ever would from overcharging their patients. As far as knowing how reputable a clinic is, I have found that most clinics, especially ones who would offer this type of treatment, have several ways for patients to leave feedback. Between Healthgrades.com, Yelp, Facebook, and Google (to name a few) you should be able to find feedback, as patients who have a notably good or bad experience with a physician are apt to share their experience with others. Good luck and thanks for reading!


          • My doc charged me $2000 for a stem cell with PRP for my shoulder tear. They couldn’t get my blood drawn. They tried 5 times in my arm and once in my neck. This has never happened to me. So he skipped the PRP and did the stem cell injection. My arm was moving better in the office but now I’m back to where I’ve started. Still in pain and my arm still stiff and crunchy. How do I even know he injected me with a stem cell and not a cortizon shot???? They returned $500 to me since they couldn’t do the PRP. Just sucks spending $1500 out of my pocket and I’m still the same. This was done January 30, 2017 Monterey, CA.


        • I live in Australia can this be obtained locally as I am a candidate for multible knee replacments


    • Would like to talk to you privately and refer you to a “real scientist/physician” who is well respected and has published hundreds of peer reviewed articles on cardiac stem cell use. He saved my life


      • Happy to talk to you privately. How do you want to make contact as I don’t believe it is proper to put email addresses on this site. Can start with Facebook message.


      • A real physician in cardiac stem cell use – why don´t you name him so we can all check it out?


  6. I have very good experiences with a PRP-treatment of the ankle of my brother. He was suffering from avascular necrosis for 7 years before he tried PRP and he was healed by PRP.

    Our experience is just n=1, but maybe other readers of this blog have used PRP, too?


    • I am receiving treatment for severe osteoarthritis of right ankle.

      I have previously consulted two surgeons and was a considered a candidate for ankle fusion with no cartilage left in my ankle. . My mobility problems was getting severe but ankle fusion was terrifying due to permanent lame condition that would result with a “successful” outcome to control pain.

      I have been treated with PRP followed 6 weeks later by autologous stem cells from fatty tissue taken from my mid-riff, then PRP again after another 6 weeks.

      5 months after the initial treatment I have improved greatly with regard to pain and functioning of my ankle. I used to walk with difficulty, for limited distances and use a cane. Now I only use a cane if I am going for a very long walk or a hike.

      Following the stem cell injections my ankle pain and foot swelling worsened for 3 weeks, and then suddenly started to become better. At 6 weeks after treatment I estimated a 60-70% reduction in pain, and some modest improvement in functioning. The clinical assistant told me that regrowing a cartilage layer even a few cells thick would dramatically decrease the pain compared to bone on bone contact. This seems to have been true in my case.

      It has been 10 weeks since my last follow-up PRP treatment and I continue to improve steadily at a slower rate, such that every two weeks or so I am in a noticeably better state. I normally have only slight pain in my ankle, but find it starts to significantly hurt after 2-3 hours of physical work. If I then sit down for a half an hour or so I am recovered. I only use a cane if I am going on a long walk or hike. I estimate a total pain reduction from pre-treatment of maybe 85-90% and greater than 50% improvement in functionality of my ankle (stability, rotation, strength, etc).

      I have opted for additional follow-up PRP injections. My naturopathic doctor says it is way too premature to consider another round of stem cells, and they may never be needed. The cost of PRP-stem cells-PRP treatment was $4,500. My insurance has covered some of the naturopathic consultation costs, so that number has been reduced by a few hundred dollars. Follow up PRP injections that I am initiating are about $600 each at 6-8 week intervals. I plan to continue this for another 6 months or so to gain maximum benefit from the stem cells.

      One final note for people with ankle arthritis. The rotten ankle joint had caused some of my mid-foot bones to shift out of position. The PRP is helping that and they are strengthening and returning to the proper alignment. I always felt like I was falling over on the bad ankle side. I have found that wearing “zero rise” shoes (no elevated heel relative to toe) or negative rise shoes (remember “Earth Shoes:?) to be very helpful.

      In my case, stem cells and PRP injections appear to be saving me from becoming permanently disabled. I can’t understand why it hasn’t been fully documented by clinical trials already.


      • Thank you for your detailed and very informative response Felix. My mother is 85 years old and had a very bad fall 4 years ago when she broke her left ankle and her left heel. She had pins inserted and when these were removed the ankle seemed to collapse inwards hours after the removal. She is getting a great deal of pain in the ankle joint probably because the cartridge has worn out completely and there is bone grating on bone.

        Do you think that this condition would be helped by the treatment and who would you recommend that I go to to enquire further.? We are located in Auckland, New Zealand Auckland. Do you have any contacts or suggestions for here?


        • I am not qualified to answer you. But I read if you have pins or hardware of some kind that the stem cell won’t be of much benefit.


      • Hi Felix
        I have severe OA in my right ankle but with hardware as well. Do you recall where you heard that it is less effective if there is hardware in the joint? Please respond as you are the only person I’ve found who has shared in the pain of localized OA and has had treatment.


  7. I have had 17 stem cell treatments. Some were autologous only, some were allogeneic only, and some were mixed autologous and allogeneic. I have SLE and I am holding my own with a reasonable quality of life. My disease is progressive and if I do nothing I get worse and will die no matter what. So the SC treatments have kept me going. For the first 24-48 hours after a treatment I feel like I can conquer the world. After that, real healing starts about 2 weeks after treatment and I can detect a noticeable difference. I have had treatments on West coast, east coast, and in between, different clinics. Cost has averaged out at 5K per treatment. I discovered the clinics by word of mouth. Some I would refer people to depending on their problem(s), others I would not.


    • Where should I go for knee injections? I have both knees bone on bone because of osteoporosis and RA. It’s progressive. Please help.


      • Dear Karyna, I apologize to you for not answering sooner. I have had the most success at two stem cell clinics. One stem cell clinic is in the Pacific Northwest, and the other is in the mid-Atlantic East coast area. Both used endogenous stem cells isolated from a blood draw, either one’s own stem cells or stem cells from a matched ABO-blood group donor. I would recommend either clinic. I am currently using the clinic on the East coast because it is closer to my home. After the first of the year (2017) I will be going there for my 21st stem cell transplant. As I have stated in the past, my disease, Stage-IV SLE, is a chronic progressive degenerative terminal disease, which necessitates periodic stem cell transplants to maintain a reasonable quality of life. Take care, Edward.
        (Editor’s note: at this time, information that can be used to direct people to stem cell clinics selling unapproved therapies cannot be included in comments. This comment has been edited in that regard).


        • I had osteoporosis, and the best thing you can do is start supplementing what your bones and joints are made of in addition of or without having stem injections, taking in any liquid calcium magnesium, with d3 mineral supplement in addition with a glucosamine and gelatin supplement for your joints is your best bet, as if you only get stem cell treatment without having the raw materials your bones and joints are made with it won’t be even nearly as effective, you’d be trying to make cells your joints and bones are made of without having what they are made of in your body.
          Hope this will help you.
          <3


          • Dear Matt L,
            Very well said. One cannot just get a stem cell transplant and expect it to do everything, regardless of your lifestyle or nutritional status.


  8. @Donna,
    I’m curious if the clinic discussed risks with you? Did they make any claims about what % of patients are helped? Did they mention up front that a 2nd treatment might be needed or only after the 1st one didn’t work?
    Thanks for sharing your story.
    Paul


    • I had it jab at my side of my hip. Whole body skin feel firm n baby skin but side effect I hav terrible itchy hives till I hav to see doctor for medications to stop the itch.


      • How is your hip feeling. I serious OA in my right hip and I am thinking about doing this.


        • Ask questions at the clinic or better yet email them to talk to a patient consultant. Find out what will be in the injection, its not always just stem cells. Make sure you are not allergic to anything in the injection.


  9. For those of you who have shared your stories as patients, am I right in thinking there was no insurance coverage and you paid yourself for the cost?


    • Hi there — insurance does not cover the actual treatments because these treatments are not FDA-approved, so yes they are out of pocket. However, you can use your pre-tax FSA funds, so you may want to take out the max for next year if you can wait that long. Some insurance companies will cover the consultations. Mine does.


      • Dear Gina,
        I agree. Also, IRS will allow costs for experimental treatments (treatment, travel, hotel stay, but NOT food) on your 1040 long form if you itemize your deductions.


  10. Edward,
    Thanks for sharing your experience. Was the clinic upfront that you may need repeated treatments before you even got the 1st treatment? 17 treatments seems like a lot — over what period of time did you get these? Have you had any side effects?
    Paul


  11. @Jim,
    I appreciate your comment on your experience. Do I understand correctly that you were instructed by the clinic to self-administer by inhalation the PRP?
    Paul


  12. Hi Barbara,
    Thanks for sharing your experience. Is your stem cell treatment by inhalation or IV administration? Some other route? If the treatment is not through the airway system, but given into the blood, how did the person doing it explain that it would work for COPD?
    Paul


    • @admin IV (first pass is the lungs) and nebulizing. The study was done under IRB approval. I signed a NDA, but suffice it to say that the treatment was very helpful and I would recommend stem cell treatment to anyone suffering from COPD.


    • I had the stem cell treatment for my COPD. It has improved my o2 level from 93 to 94% I now have an o2 level between 95 and 97%. I do however have a very ugly side effect from the treatment. I am suffering from ongoing nausea. It has gotten so bad I spent 5 days in the hospital and am currently on 3 medications to try to control it. I also have to go get shots at least twice a week because the meds just don’t work well alone. I think it is a wonderful treatment but if I had know about this side effect I don’t think I would have jumped in so quick. I did do a lot of research and nothing mentioned nausea. I paid 5199 for the treatment in Tx. I received the treatment thru IV and also thru inhalation.


      • Katheryn when you went in the hospital because of getting sick from stem cell treatment did your insurance pay the hospital bill or did they refuse because you had stem cell treatment.I have copd and was thinking of doing a stem cells in New York on clinical trials.gov.NCT02216630 it cost about $7,500.they use your fat to get the cells from but they also have another type of treatment.They told me they would use younger cell in a nebulizer treatment for $2,500 and I would not have to do the Lipo suckishion.Has anyone done this treatment from Dr Ross on clinical trials please let me know.deegeardino@optonline.net. I really would like to know if you had a problem with the insurance in the hospital.


        • I have performed stem cell treatments on many patients with COPD both IV and through nebulizer. Nausea has never been a problem for any of our patients. We only use the patient’s own stem cells for 2 reasons. 1) there are reports of rejection of other’s tissues and 2) while growth factors and other catalysts from another person’s tissue may reduce inflammation temporarily, your body cannot build new tissue using tissue of another person.
          Katherine Knoll


          • @Katherine,
            What kind of stem cells do you use? Do you have any kind of FDA approval? Do you have any data to back up what you are doing?
            Paul


            • Autogolous
              FDA has no problem with what we do
              Data can be had by speaking with our very happy patients!


  13. @David,
    Thanks for telling us about your experience with stem cells. Have you had any cardiac function/imaging tests that show improvements or is it based on how you feel?
    Paul


  14. Insurance does not pay for experimental therapies, which stem cell treatment is considered. However, there are other options: clinical trials under IRB (Institutional Review Board) oversight for safety clinical trial, efficacy clinical trial, pay for cost clinical trial, etc. However, need to do homework on clinic, physicians, trial investigators, and any scientific publications to add validity to their work.


  15. Dear Paul,
    SLE (systemic lupus erythematosus) is a nasty progressive autoimmune disease that will cause a myriad of inflammatory problems in every organ of the body. Without continued treatments I would have died. But to answer your first question, No, they had no clue how many treatments I would need. I have received the treatments from multiple clinics over a period of five years and counting. When I start to regress from my last treatment I receive another treatment. An unexpected side effect occurred with the first allogeneic treatment. Once the particular problem was realized, it has not been repeated.


    • Thanks, Edward, for the reply to my question. I’m curious do you also take any non-stem cell treatments for your SLE?
      One of the other aspects to these stem cell treatments that I’m interested in is to what extent patients stop taking “conventional” pill/shot kind of treatments based on chemical drugs and switch over to stem cells OR if they more often combine the two.
      I wish you all the best.
      Paul


      • Dear Paul,
        I started with a board-certified Rheumatologist some 21 years ago after being diagnosed with stage-II SLE. I began with a “flavor of the month club”, i.e., AMA-approved chemical treatments for SLE. Basically there were/are none. But I tried multiple versions (singly and in combination) of prescribed antibiotics, antihistamines, corticosteroids, quinine, opioids, immunoglobulins, low dose chemotherapuetic drugs, etc. Nothing halted the progression of my disease, and in some instances actually accelerated its progression.


      • For 16 years I steadily progressed to stage-IV SE (death is stage-V). After a conference with my Rheumatologist in which I was told that the then symptoms I was showing was indicative of terminal lupus (death imminent) I decided on a stem cell transplant. That was five years ago. The stem cell transplants have done more for me than any AMA-approved chemical treatment. Currently, I try to restrict any activity that would cause an inflammatory response (i.e., lupus flare/crisis) resulting in the systemic deposition of scar tissue and decreases in functioning organs. Thank you for your empathy, it has been an interesting five years.


  16. I had an amniotic stem cell transplant into my right shoulder sixty days ago today.
    I had planned an IV transplant one month later if the first one was successful. After 30 days there was no difference in my ROM, pain and function. Today my crepitus is decreased by 40%, ROM improved by 40% and chronic pain at 1-2 vs 6-8 prior to the transplant. I am again considering IV transplant in about four months depending on my continued improvement in my right shoulder. The cost of the injection transplant was $5,000 and the IV was to be $4,000. I am a retired RN with 33 years experience, the last 20 years in a very busy large department in Sacramento. I also taught EMT’s at two college campuses in the Los Rios Community College District for twenty years. I’ve had several intra joint injections of corticosteroids so am experienced with the technique.
    The stem cell clinic was state of the art with the newest technological equipment. An RNP both did the initial consultation and after one hour I made the decision to proceed. She also performed the procedure with the utmost sterile technique. I held and examined the vial of amniotic stem cells prior to injection and inspected the label which was a FDA approved laboratory. This was shown to me during my consultation visit. The NP’s technique was so good with messaging the joint after injecting local anesthesia for about ten minutes. During that time the NP showed me several torn tendons in my shoulder and pointed out my “shredded rotator cuff”. I barely felt the stem cell injection needle, uncomfortable but certainly not painful. It was injected very slowly and I could see the stem cell liquid enter my shoulder joint from the needle on the Ultrasound. I had absolutely no post-injection discomfort.
    I never saw or met an M.D. while in the clinic.
    I spent several months researching this treatment including your website and had the full bio of the RNP before going to the consultation. I was very candid with her and she was equally as candid with me as we discussed her training, experience, and knowledge. I was very comfortable with her and would not hesitate to return for another treatment administered by her. I would recommend this clinic to anyone with joint disease or degeneration.


    • @Roberta,
      Thanks for the detailed description of your transplant experience. There’s been quite a bit of discussion about amniotic transplants. The biggest question at this point seems to be are the “amniotic stem cells” administered by the clinics (A) actual living amniotic stem cells or (B) protein extracts (i.e. no living cells, but material taken from stem cells at some past point).
      Did you have a sense from your experience what was used or was it not clear in this regard?
      Paul


      • Paul,
        I did not ask that question but the vial was refrigerated when she obtained it and asked me to hold it in my hands for the ten minutes she was messaging my shoulder after the local anesthetic agent was injected to warm it up prior to the injection. Does this help? Thanks, Roberta


        • Thanks, Roberta.
          Maybe things weren’t clear during the experience of getting the transplant, but what was your assumption/gut feeling at the time?
          Living cells? An extract?
          Did they say “stem cells” or “stem cell extracts”?


          • Paul,
            I felt she was using stem cells the entire time. The word extract was never spoken. In retrospect I wish I had asked her to keep the empty stem cell vial.
            Next time I will if I do go back.
            Thanks, Roberta


            • I know that in the ortho office I work for, we recently started doing amniotic “stem cell” injections, but they do not actually contain any living stem cells. It is somewhat deceiving as many clinics refer to them as stem cell injections, and technically they can call them that as the patients don’t typically ask whether the cells are alive or dead. I’ve even seen info from the manufacturer that did not come right out and say it contained stem cells, but instead gave info on some stem cell attributes that could be easily misconstrued. We carefully explain the injections to patients, and have not had any decide against treatment afterwards.


              • There is no documented evidence that amniotic fluid/cells(if there are any in the mixture) are effective.
                What I am reading here all points to “Sham treatments’. There are many seemingly reputable doctors and clinics offering hope to desperate people if you an pay for it. Many of you are being fooled into thinking these procedures work. It is called the placebo effect. As a Nurse practitioner and a stem cell recipient patient I have done more research than the average patient and have looked at and been in clinical trials.


    • Thanks Roberta for you comments on amniotic stem cell treatment for your shoulder. Appears the clinic you had the injections is the one I plan to see for stem cell treatment for my neck disk degeneration. (Nervana, Robin?) I asked how many treatments they have done on the neck and back and was told they have done hundreds. May I ask how you rate this clinic’s expertise, operation and professionalism? Would you recommend them? If you like to reply to me only, my email is awau@email.com

      And how is your shoulder now some 6 moths later?
      Thanks
      Andy


    • I too had amniotic stem cells injected into my shoulder (left). I have had two treatments, averaging $2k each. My ROM has increased greatly, and my level of pain has dropped from a debilitating 8 of 10 to 2 to three, depending upon my level of activity. The clinic serves major professional athletes in the Pittsburgh area, was clean and state of the art. I am a believer!


  17. A full accounting of my experience would have to identify the clinic. Since the rules preclude a full accounting, I can only say this.

    I suffer osteoarthritis in one knee as a consequence of letting a surgeon loose on my medial meniscus back in early 1970’s. (Don’t ever let anyone do that to you!)

    I was not cured by my autologous bone-marrow stem cell treatment but my condition did improve. I cannot “prove” that my improvement was due to the stem cells or whether the improvement was caused by some other aspect of what was a very comprehensive treatment plan.

    It is important for me to point out that the doctor treating me was very clear that I was paying for an experimental treatment. I had read multiple peer-reviewed publications and had come to the conclusions that the treatment had a high probability of being safe and a small chance of a cure. My analysis was that other types of condition (eg tendon injuries) would be more curable using the same basic approach — which I broadly characterize as amplifying natural healing mechanisms.

    As a scientist, I am well aware of laboratory costs and I judged that the price was in keeping with the nature of the treatment. (Which, again, I can’t get further into without identifying the clinic.)

    Stem cells aside, I would highly recommend the doctors who I cannot name at the clinic that I cannot name.


    • @Brian,
      Thanks as always for weighing in and in this case talking about your experience at a clinic. I’m glad to hear that there was an emphasis in this case that what you received was experimental. Did they talk about potential side effects? Paul


  18. I’ll weigh in for my dog Ruby who is a sheltie X. She is 15 years old. She was very arthritic and having problems getting up from a seated or prone position and was falling fairly often. She had an adipose derived stem cell treatment a few months ago. She also gets laser therapy weekly. She is now able to get around easily and even breaks into a run now and then. Her cells are banked if she should need another treatment, but at this point, there is no need for it.

    The other option we were given was a host of steroid injections and pharmaceuticals, including pain medication. We chose not to do that and are extremely happy with our choice of stem cell treatment for her.


      • Her stem cell treatment was around $2500 which included X-rays and post treatment care as well as the banking. The laser treatments are complimentary at her primary vet’s office. He allows pet owners to come in and learn how to use the laser and then treat their pets at no charge. She is doing so well. It was worth every penny. She was so frisky today that no one would ever be able to tell she is 15. She also takes a joint supplement called Joint Max. I think many vets that offer laser have package plans. We are lucky that her vet doesn’t charge for it. Laser is something that you need to continue to do to reap the most benefits.


  19. @ Paul, Yes, side effects were mentioned. The only side effect that I had was a little bit of back pain following the marrow draw. It soon resolved.


    • I had stem cell treatment in Madrid, Spain, my experience was great with my diabetes, alter 6 month I noted my HbA1c decrease from 7.6 to 6.1 and actually no Longer I use insulin.
      I paid $6,500.00 Euros and no I thought it is an reasonable price.


      • Can you provide evidence? I assume you’re talking about early stage type II diabetes – which has a high rate of self-correction with diet and exercise anyways – anything else is not possible, especially type I where the pancreas tissue is not there to be saved.


      • Hi! I am curious to know too if you are type I or type II? Can you please let me know, as I am considering stem cell therapy for my diabetes too.

        Thank you.


  20. I very much appreciate the level of research people have done, as I also did. This demonstrates that the risk of vulnerability to “snake oil” treatments can no longer be cited with the urgency that existed before the average person had so much information available to them.


  21. @Paul. Yes Paul i was instructed to administer the PRP by nebulizer. I was given a dozen syringes that I kept on ice in a cooler while traveling and kept them frozen then thawed them by keeping them in my hands for a few minutes and used one, every four days. I actually feel much better now after 3 and a half months.
    I still have some issues with exacerbations but have enough experience and confidence now to know the triggers and how to deal with the anxiety.
    I have been able to get out almost daily, if just to take a drive for coffee. I wouldn’t say its a significant improvement just yet but it certainly is a start in the right direction, and i don’t feel like Im falling off the cliff to spiral downward. Im happy just with a baseline like it is. I also found that N acetyl cystein – 600 mgs 3 times a day has aided me in lysing mucus production.


  22. 1. Injected MS maintenance drug daily for 5 years with terrible side effects. Other approved MS drugs offered had possible life threatening side effects, or I was unable to take due to exclusion criteria. Had one round of MSC’s for MS in 2012 with many quality of life improvements lasting to date. Two of the most helpful conditions eliminated were heat intolerance and fatigue. Cost can be anywhere from 10K-25K.

    2. In 2015, had 2 rounds of PRP over course of 6 mo., in right heel. PRP completely eliminated an extremely painful case of plantar fasciitis. Aprox $500 per treatment. I’m free of condition to date. Can walk/hike and go about daily living without pain. Option for traditional treatment were steroid injections or surgery with no guarantee of eliminating condition.

    3. Opted for a bone marrow aspirate during arthroscopic surgery to treat ACL skiing injury in left knee June 2015. Injury had no possibility of healing on its own. Had full recovery. Was hiking, biking, walking in 6weeks with a completely functional knee. Skiing full speed 6 mo. later. Costs aprox 5K. Traditional methods of knee repair were using a cadaver tendon or taking part of my hamstring muscle to repair injury, creating another injury. Traditional methods would have required 9-12 mo. intensive rehab and narcotics to treat pain.

    Each condition mentioned above was treated at a different clinic. I’ll chose my own cells over outdated more invasive options every time.


  23. Paul I have copd and I am looking at going into a stem cell trial on clinical trials .gov. The trial number is NCT02216630 you still have to pay for this your self,and they have one close to me in Manhatten N.Y. they use stem cells from your fat in your belly.I am a little scared of this,I just don’t know what to do at this point I am on oxygen 24/7. I am not sure I can inhale the glutathione ,besides were would you buy that for nebulizer med.Has anyone been there? Dee Geardino —e-mail address deegeardino@optonline.net


  24. @deegeardino You can ask your doctor to prescribe a nebulizer for you which will then be provided by your oxygen company or you can easily purchase one online.


  25. @admin,
    Yes I had an Echo Cardiogram that showed the improvement in heart function and also blood tests that showed kidney improvement. As said previously I am going to have another Adipose Derived Stem Cell (ADSC) before end of June. Prior to next treatment I will have another Echo Cardiogram and other required tests to set a base line point again. It will be interesting to see now after six and a half years where I am at now and then to see if any improvement a few months later after my next treatment.

    On another note my wife is also having a 2nd treatment for Arthritis. Her 1st treatment 6 years ago improved her condition greatly. She now feels it is time to have another treatment as some joints in hands and feet have started to hurt again. The 1st treatment also fixed her long distance eyesight and she did not need glasses any more. Confirmed by optician. It also seem to fix a old whiplash injury from 30 years ago. The ache/pain in her neck/back went.


  26. I’ve had four regimes of stem cell transplantation for multiple myeloma. I am alive because of good communication between my doctors, and I believe this treatment was highly effective.

    The stem cell transplants treated my multiple myeloma by restoring bone marrow with healthy cells, which later stimulated new bone marrow growth and aims to restore my immune system. I have not had convincing results with my immune system, but I am alive and in relatively good health.

    I underwent a conditioning regimen, involving intensive chemo therapy treatment aimed at destroying as many myeloma cells as possible. After nine months of therapy, my oncologist gave the green light to undergo the allogeneic stem cell transplant treatment.

    In the months following the transplant, my blood was regularly monitored my blood counts. I required numerous transfusions of red blood cells and platelets. I was told that my intensive treatments that I received before the stem cell transplantation was the source of my awful and stubborn infections. I was administered IV antibiotics to combat this. I was also prescribed a 2-year regime of drugs to reduce any risks of graft-versus-host-disease.

    At this point in time, I celebrate three years of remission. I’d go through the pain, discomfort and lengthy treatments all over – I mean, I was fortunate to have my condition diagnosed because of a bicycle accident. If not for a stupid driver, I might not have had treatment options.


  27. @deegeardino I would think before they give you glutathione they would check for sulfites in your urine. If you are on o2, 24 -7 you should be on nebulized medications already. I haven’t been to that particular clinic but I have gone to their competitor in Florida whose overall protocol is slightly different.
    From (the study you reference) what I understand, in their Manhattan location they do a secretions followup in nebulizer. Perhaps the glutathione you speak of. It is not yet indicated or approved for use in COPD. They also bank and grow a million extra concentrated adipose derived cells for a 6 month followup in the included price of 7Gs. In the clinic i went to, i took nebulized platelet rich plasma home instead of secretions. Would I recommend the procedure to you.
    Yes!! The cost is ridiculous I know but for your psycholigical well being I would recommend you give it a try if you can afford a treatment.


    • JIm, That office told me they wanted to use younger stem cells with me and I asked them what about redjections they than said there was no stem cells in it,it was called secretions what ever that is.I talked to a doctor yesterday that works with trials and there was a big stem cell meeting over these clincils .They haven’t stoped them because they are not using stem cells so they are not really breaking the law.He said to wait for Pittsburg to post on clinical trials.gov they are working on stem cell now. Dee


  28. ^^^ Clarification and edit of above post* “Perhaps the glutathione you speak of. It is not yet indicated or approved for use in COPD.”

    Glutathione is available for nebulizer by prescription for copd. The usual starting dose is 300 mg of glutathione (200 mg/cc, draw 1.5 cc and place in nebulizer) twice a day. Note: Patients with cystic fibrosis and other respiratory disorders can benefit from this therapy; however, it may cause bronchoconstriction in those with sulfite-sensitive asthma.


  29. To Jim Hannan, I am afraid of the Glutathion because I get broncho spasems every once in awhile where my throat closes up and it is very hard for me to to be able to get my breath right it feels like I am breathing thru a very tiny opening in my throat it is very scary.That happened once when I was using my Nebulizer.That is how I stopped smoking. I had a coughing spell and lit a cig to stop it and it closed my throat right up,never smoked again that is how scared I was,I try not to panick when this happens.I wish some people would spell out some of the thing they are talking about instead of abbreviate some things like BSCs Thank you Dee


  30. I would like to see any comments on using adipose derived stem cells from “belly fat” to treat neurological diseases such as Charcot Marie Tooth. The reply about using adipose stem cells to treat a dog was interesting. After some consideration,
    I decided not to undergo a test procedure, where adipose stem cells from (belly fat
    fluid) would be by IV into my blood stream and some 30 injections into the calves
    of my legs. The first treatment would be $8900 in early year 2015 and less if more were needed. This was to treat my hereditary disease, where nerve cells
    were being damaged by genetically defective t cells sent by my brain for normal
    replacement of nerve cells. A big question is how long will the treatment last, since the brain will continue to send defective t cells. As a temporary fix, the time
    where gain in mobility is improved is of most interest not to ignore safety. I will most likely not live long enough to see a gene modification procedure created to correct genetic diseases.


  31. I was diagnosed with progressive MS 20 years ago. By 2010, I could barely stand up, needing to sit down after a minute, and walking was excruciatingly difficult. June 2010, I had my first Stem Cell Treatment, a combination of my own adipose fat stem cells and umbilical cord stem cells. Results from this first treatment were very impressive. My legs were extremely strong and remain so to this day. I can stand up for an hour or longer if needed. My bladder was almost completely repaired. Prior to stem cells, I incontinence was the state of my bladder. That was not the case after that treatment.

    I receive stem cells once a year. The second treatment gave me no repair but I did receive that blessed relief from fatigue and weakness for about 6 months. The third treatment brought some kind of repair to the nerves leading to the bowels. I was now having a movement once a day instead of once every 10 days. I think this was huge.

    This last treatment made some repairs to the hip flexor muscle on the right side. Or should I say the nerve to the hip flexor muscle was repaired. I cannot lift my leg on the right side and before the treatment I was not able to lift it off the ground at all.

    So I need to clarify one thing. The last two treatments have been strictly umbilical cord stem cells.

    Judi Lecoq


    • Dear Ms Lecoq,
      Were the umbilical cord stem cells you received from a male or a female or from both?


  32. I failed to mention one very important point. A recent MRI completely baffled my neurologist, showing no active MS and two very very small old lesions that were not active. Woohoo!!! Stem Cells work!


  33. Jim Hannan,what is the secretions follow up you talked about,the N.Y clinic did say something about that but I did not understand what he was talking about, Jim could you write to me on my web address. deegeardino@optonline.net. There are a couple of things I would like to talk to you about.


  34. If you don’t mind my asking; where did u go to get this done? I am also on fb in nj- Thanks


  35. I had shoulder replacement surgery in the August 2011 which deteriorated by May 2014 (Osteolysis) with considerable wear of the plastic glenoid component. The TSA was revised, the glenoid piece removed, holes in the shoulder blade filled, anf the ball on the humerus changed for a larger one to take up the gap left by the absence of glenoid piece. The net result is an arm that has decent mobility but continued pain. As a serious side-effect of this operation is damage to the nerves which resulted in a lack of feeling in some of the fingers in my right hand, and a displaced nerve on the inside of my right elbow.
    Given my history with the right shoulder, and with the left shoulder becoming increasingly painful, I went to a local “pain clinic” (Crystal Coast Pain Management), seeking help. For about 10 months they shot the shoulder with steroids which became increasingly less helpful. The Dr. then referred me to Aegean Medical at the same location. They performed a Liposuction procedure, processed the results of same, and injected it into the left shoulder using fluoroscopic guidance.
    This cost me $2750, and resulted in some belly pain, but no discernable effect on the aching shoulder.
    Unhappily, I’m facing another complete shoulder replacement, or what ever the Duke Orthopedic establishment thinks is appropriate.


  36. I had Adipose Stem Cell Therapy for Multiple Sclerosis 3 years ago in California. I have had no real improvement and my stomach, where they took the fat, has so much pressure it feels like my stomach is hanging over my legs. I am not overweight but it feels like I am. Has anyone else experienced this?


  37. Please is anybody knows anything about stem cell of America email me at khalene.hassler@aimhomehealth.com. I am desperate for any information because my baby boy needs a miracle we have an appointment next month with stem cells of anything. Any thing you know please please.


  38. A cohort of 26 successive patients undergoing allergenic noncumulative stem cell transplantation is obtainable, all of whom were given a mixture of flabbiness and ATG. Patients’ characteristics are described in Table. RESULTS
    The allergenic noncumulative stem cell transplantation procedure was much better tolerated in contrast with the likely side belongings next a criterion myeloablative routine. As can be seen in Table, listing ordinary procedure-related toxic manifestations, next allergenic noncumulative stem cell transplantation no grade 3 or 4 toxicity (World Health association [WHO] criteria) were experiential in any of the recipients. For more information please visit at
    http://www.calweststemcell.com/


  39. On Sunday September 11, 2016, I received an amniotic stem cell injection for my right Achilles tendon. When I left the clinic I began to have a sore throat. Then as time progresses I had flu like symptoms.

    My Achilles had pain on and off. I continued to have flu like symptoms. By Thursday I had difficulty getting out of bed due to flu symptoms. I felt better once I was out of bed.

    I started feeling a lot of pain in my Achilles as the day progressed. By the time I went to bed the pain was unbearable! I couldn’t sleep at all that night.

    I talked to the chiropractor who was involved in this treatment. He said this meant the stem cells were really working. He said the doctor who gave me the injection could prescribe me a narcotic but I would have had the drive from San Diego County to Orange County to get it.

    I decided not to do that. Throughout the day I have no appetite because of the flu symptoms. I then started having severe pain in my right knee! I couldn’t move! I had pain in my lower back as well.

    I broke down and took Alleve. They advised against it but I was in so much pain I could hardly move!

    They said 300k received the injection with no side effects.

    I’m very disappointed! I paid $4500 for this injection to have days of misery and pain not going away by itself!


    • Wow Dee, you seem to have had a strong reaction from the stem cell injections, that was aggravated by your having the flu going in to it. Were you advised to apply ice or to stay off the foot for long periods of time? Did you get much advice at all about aftercare?

      I had a PRP (Platelet Rich Plasma) injection done on my left thumb joint on 9/14 which are suppose to be more painful than amniotic stem cell injections. The first day they did advise me to put ice on the area of the injection for 10 minutes on and 10 minutes off for several hours but the next day there was no pain at all and I actually got a 9 day break from the searing pain I’d been experiencing for many months! (Like someone slicing my thumb open from the lower palm to the second thumb joint!)

      It only started hurting again on Friday 9/23 but still the pain is no where near what it had been.

      I hope you still get some relief. The clinic personnel I was treated by in FL, said some people do have an inflamed response to stem cell injections and that it is always very individual with no way to know who will react and who won’t.

      I’ll write more soon about the amniotic stem cell injections I had on both knees last month for which I had no painful reaction (which worried me as I wondered if the stem cells weren’t working), but so far the results are very good.


    • heavens only knows what you were injected with but I have not heard of a reaction to stem cell injections ever. Secondly NO Chiropractor is qualified to do any thing like the procedure you described. You do know that chiropractors are not doctors. They have less than 2 years of training and have caused very serious problems in people including death. Run from those guys.


      • Chiropractors have 5 years of training beyond undergrad and are licensed in every state and yes they have doctorate level education and credentials.Many practice in medically integrated clinics as well.The side effect rate from treatment is the lowest of any health care profession as well


  40. In ’04 I had to have meniscus surgery. In ’10 I hurt my lower back being a stupid man thinking I could move something heavy to a new rental house. I felt 5 rapid pops in my lower back. No pain. I did some stretching and went ahead and moved the stuff.

    Went to a huge teaching hospital in the Kansas City Metro Area. They did steroid injections into my knee and into my spine. L4 and L5. They worked once, but never again.

    I finally found a pain management doctor. I’m on opiods which work, but only give me about 3-5 hours of ‘up’ time.

    On August 8th he did a stem-cell prp injection into my right knee. The stem-cells he used (I forget the name) were from placenta and umbilical cords, which had been neutralized, etc. in the lab. The prp was done via a blood draw. Plasma Rich Platelets. For 3 days it hurt very badly. Because of the pressure in the knee area. But within a week, it wasn’t hurting anymore. I could feel things happening in there, but, it seemed to stop to a post operative condition, which was better than nothing. As much damage as was in that knee, I knew it would probably need several treatments.

    Then there was the back. My pain management Dr. wasn’t qualified to do this. But he knew someone in Kentucky. NOW THIS IS SOMETHING I WANT TO TELL YOU AND I WANT YOU TO READ, IT HAPPENED BETWEEN A FRIDAY AND A MONDAY.

    On Friday my paint management doctor told me that the KY doctor would be calling me Monday. Also during that weekend I went to my pharmacy to refill scripts. I got my Hysingla and it was a lower dosage. I went ahead and accepted it. MAJOR mistake. I came back in on Sunday to get it straightened out. They had filled a prescription that was stuck in the system from 7 months ago. Then Monday comes. No call from the AR doctor. Then Tuesday comes and I call him, he returns call. We chat. I send him e-mail like he asked. Then Wednesday……My pain management Dr. starts slamming me with texts about coming in with a 7 month old script. The pharmacy told them that I came in with it, which was a total lie to cover their butts. The pain management eventually called me and we worked it out, as I’ve never lied or failed a drug test with them. Then, later that day he sent me MORE texts that I shouldn’t of gone around his back and talked to the AR Dr. He then told me that he would not allow his friend to work with me.

    He said he’d refer me to a local

    So my advice to anyone reading is to be very careful what your pharmacy is filling. I don’t know how to tell you to find a good pain management Dr. because in Kansas City they are seriously hard to find. The FDA isn’t making it any easier either. Drugs like tramadol and tizanadine do NOT work for me. These are newer generation drugs that work on the receptors of the mind and don’t go to the site of pain.

    Anyway, sorry for the long story, but you asked for it. I’m desperate to find another place that will do stem-cells and prp in my right knee again and in my lower back. There’s always that company that begins with R, and they have an office in Kansas City, but, they are sooooooo expensive.

    I don’t have family to speak of. Just me and three dogs. I just want to enjoy life again and at 55 I’m not ready to give it up but if I go back to the pain I WAS in, I’ll wind up ending it by my own means.

    You’ll find it difficult to find people who even can comprehend chronic pain.


  41. I was recently diagnosed with FTD with PPA, and I was considering stem cells, the few doctors I spoke with said that the treatment either stop the progression or reverse or slow it down…has anyone used stem cells to treat this disease ?


  42. I am considering using umbilical cord stem cells for my autoimmune disease because I’m too thin to have the liposuction procedure here in the US. I’m wondering if anyone has travelled to Panama for treatment and if so, what was their outcome?


  43. My husband and I are currently chatting with a clinic about getting him treatment. He had back surgery in 2000 for a herniated disc with discectomy at L5-S1. His sciatica is so bad right now he is absolutely miserable. Family dr says they probably will not do surgery so we found this clinic. They use amniotic stem cells from C-section donors. The cost will be around $7,000. We are in the process of getting his CT scan sent to the clinic – I was relieved when they asked for it as I took this as a sign that they were not “snake oil salespeople”. I am currently looking for accreditation information on the clinic and their doctors. My friend’s sister had this done at this same clinic. She was waiting for a hip replacement and had severe osteoarthritis in her knees. She had injections in both her knees and her back (she thinks that they were wrong about the hip replacement recommendation). She went from a wheelchair to my friend not being able to keep up with her in the mall. It should be an interesting experience. We will just have to cash in some savings/retirement investments and try 🙂 Prayers for healing for all – chronic pain sucks.


    • Hi Tina. I just had stem cell injections done in Barcelona, Spain two months ago. They used the stem cells from my own bone marrow which they processed in the lab for 22 days before injecting 1cc (about 10 million of 100% stem cells) into both my L4-L5 and L5-S1 discs. I had 2 surgeries previously. Never had them fused. Costed me about $24,000 US dollars with includes the preop tests. They’ve been doing this for 10 years over there in Spain and even longer in Germany. They say results are about the same 85%-87% as an artificial disc replacement. But this stem cell treatment takes longer. What I mean is the stem cells don’t even start to transform and heal the body until 4-6 months after the injection. While most people are feeling pretty good a month after they get an artificial disc.

      That said, I still have pain as it has only been 2 months since the injection. But I’ve been able to reduce the level of pain some through exercise and other means. My idea behind choosing stem cells over an artificial disc is that it’s way less destructive to the body than having surgery. Surgery creates permanent damage. So I wanted to try this first before having a third surgery.

      Its important to note that stem cells alone will not do much to suck in the herniation or increase the disc height. But if there is still enough room for the nerve roots to exit between the vertebrae and the herniation bulge is not too severe it may be a good option. But I think stem cells may be good anyway just to repair damage and regenerate tissues in general. Just my personal opinion.


      • Thanks for your comments David. It’s a good description of what I’m considering. I pray this works for you and that you are pain free in the next few weeks/months.


    • Tina, I hope everything is well. I also have sciatica from lumbar disc protrusion and considered amniotic fluid injection as an option, but decided not to. Amnionic/placenta fluids are nutritious but not necessarily have healing potential. I hear that they are great for pain relief in general, but sciatica is often mechanical issue – hearniated or bulging disc irritating the nerve.

      I decided to opt out with same day, bone marrow stem cell with platelet lysate injection to my discs in attempt to fix disc protrusion and tear issue which could potentially fix sciatica as well. I hear that the most effective treatment is massive dose of stem cell injection to the disc (order of 10 million pure stem cells), just like David described, but cultured stem cell treatments are usually 20+k USD. Same day bone marrow stem cell treatment usually have lower stem cell count, so sometimes they could be effective, sometimes not effective at all (depends on the stem cell count in patients and experties of the practitioner). My injections are going to cost me 6k USD, quite affordable for two disc injections, and I will see how the results come out. Let me know if you are interested, I will give you more information if my results are good.


      • Would certainly be interested to hear if this helps. Also interested in any stem cell treatment that was helpful for any condition.


        • Dear Ed,

          I have had multiple adult stem cell treatments (intra-nasal [neurological], nebulization [pulmonary], and systemic delivery [everything else]) for my Stage-IV SLE (systemic lupus). No cure, but has given me a better quality of life.


          • You may have a better quality of life than earlier – but you cannot infer that “it has given” you a better quality of life without mechanistic evidence and statistical significance over controls. People who read this blog sometimes take such statements as fact and they aren’t. Just sayin’.


            • Dear Archie,
              I have quantifiable objective data if you prefer. I am tested twice a year by my physicians to track my progress. Since my initial diagnosis of Stage-II SLE in 1995 my file is about 4-5 inches thick. During my progression from 1995 to 2011 (Stage-IV SLE) my health deteriorated significantly and the objective data proved it. Since my stem cell transplants began in 2011 my health has been cycling from marked improvement to stable to slightly worse to marked improvement to stable to slightly worse, repeating this scenario with every stem cell transplant (I have had 20 thus far). This cycling pattern depends on the type (autologous and/or allogeneic) and length of time between stem cell transplants. Since I am not dead yet and I can function at a reasonable level, I consider that an improvement in quality of life. The objective data mirrors this cycling pattern.


              • Edward, good to hear that you can track the changes occurring in your specific case, but this is still an uncontrolled n=1 with many confounding factors, i.e. anecdotal evidence, which cannot be extrapolated to other patients as a therapeutic modality.

                As I said, with no solid mechanistic evidence or statistical significance over controls, one should be careful how to phrase the post for those with less scientific and clinical background. You have always been very clear on this.


                • Dear Archie,
                  I agree with your assessment, a sample size of one does really nothing for the greater scheme of things, except it has kept me alive for a little bit longer. But it has also been informative to the investigator who has used my data to construct clinical trials for others. My counterpart and one of the clinicians he works with have an IRB-approved clinical trial for neurodegenerative diseases ongoing at the moment. They are performing a very small clinical trial looking at the safety and efficacy of giving the patient their own stem cells using their own unique technologies. They are doing this with individuals having ALS (Amyotrophic Lateral Sclerosis), MS (Multiple Sclerosis), and PD (Parkinson Disease). While the results are encouraging, so far they have been incremental. The way I understand it, with every stem cell treatment there has been “two steps forward and one step back”. Several things from my study and the other study that my counterpart will let me share with the general public are as follows. And this is probably applicable to any type of stem cell treatment, not just the unique technology they used on me or the others.
                  1) Stem cell numbers matter, the greater the number of stem cells given, the better the response.
                  2) Alcohol KILLS stem cells.
                  3) Stress is detrimental to the function of stem cells.
                  4) Caffeine is detrimental to the function of stem cells.

                  Take care,
                  Edward


  44. My husband is considering stem cell treatment for COPD. I have spoke with several places some treat with blood only, some with fat. I would like someone that had treated for COPD with improvements please e-mail the names of clinics in or near Georgia you .recommend. He really needs helps


  45. I had a stem cell transplant for Lupus as part of a study at the NIH 12 years ago. I also had a spinal disease called Transverse Myelitis that paralyzed me chest down for 7 years. I am Lupus free and am in a walker after 17 years in a wheelchair. I am still improving as I keep working out. The goal is to get rid of the walker at some point. Been worth that month of hell during the procedure time period but I do not regret it at all!


    • Shawn, for the Lupus trial did they use your cells, msc umbilical cord cells, or did the do full blown chemo to kill off your immune system then reintroduce your own cells? I’m contemplating umbilical cord msc for mild lupus, with the hopes my immune system will be modulated and behave accordingly. Either that or IVIG treatment. I’d like to try something before heaving yo resort to immune compromising drugs. Any input appreciated..


  46. Wow- that’s incredible- so happy for you! How did they harvest the stem cells- fat or bone or umbilical cords? How long was the treatment? I know we’re not supposed to name the clinic but can you say the state or country you had the treatment in?


  47. We have been administering amniotic transplants for almost two years, and the results have been astounding. We have tracked more than 80 patients over that length of time with most greater than 80% of patients reporting between an 80-100% improvement rating. Joints injected include knees, shoulders, thumbs, toes, elbows, ankles. Any synovial joint.

    I know there has been some controversy surrounding the amniotic transplant. But having looked extensively into it there are some inherent advantages. The good companies utilize active cell counts prior to the product being frozen, you can see the swollen live cells that are being injected from slides that are examined. I have a high level of confidence knowing what is being injected into each patient. These cells are brand new have never undergone aging and are being injected with growth factors and other matrix that assist the cells in setting up and regenerating. It is fantastic to take pre and post films particularly on knee joints and be able to show patients improved cartilage spacing that correlates with their knee pain diminishing.

    There have been three patients who have not had improvement, two underwent knee replacements after 3 weeks (the product can take up to 6 months for maximum improvement), and the third we administered a hyaluronan injection series to try and reduce additional pain levels, still undergoing tx.

    Truly a life changer for so many patients. Best of luck in your individual research.


    • @Michael,
      The details you shared are interesting. I have a few observations and questions.
      If as you indicated you are administering a living amniotic, allogeneic product to patients, my understanding is that that is a 351 drug product requiring pre-approval from the FDA.
      If you don’t have a BLA and IND from the FDA, then you could well be marketing an unapproved drug product without proper licensing.
      Also by mixing living cells with growth factors and other compounds like extracellular matrix then you seem to be making this into a drug product.
      Finally, amniotics are non-homologous to joints, further making your use that of an apparent drug product.
      Thoughts?
      Where do you obtain the amniotic product?
      Have you published your findings?


      • Admin, your comments are relevant as there is an increasing number of “stem cell” clinics offering amniotic growth factor injections. These clinics often promote the amniotic fluid injection as containing live stem cells, but they do not.

        Amniotic fluid products are generally sterilized growth factors and other regenerative proteins. The contents of the product is proprietory and often unavailable to the public.

        My experience is that the provider is either ignorant to the scientific facts or willingly deceiving their patients.

        My advice to patients seeking “amniotic stem cell therapy” is to ask for the name of the product being used, then contact that company to see if their product contains live stem cells.

        At this time, I’m not aware of a company that offers live cells, otherwise they would qualify as a 351 product and would be FDA non compliant without an IND, BLA, etc.

        However, patients can improve from amniotic growth factors injections because the benefits are similar to PRP. Further studies are warranted to study the efficacy of amniotic growth factors vs PRP.

        The health provider’s cost to offer PRP or amniotic fluid is far less than $1000. I do not understand why an amniotic fluid injection should cost much more than that. Some clinics are charging more than $5000. Not justified in my view.

        A legitimate stem cell procedure (fat or bone marrow) requires advanced physician training and overhead expenses justifying costs ranging from $3500 to $10,000 depending upon the treatment.

        Now is the time for Regenerative medicine physicians and scientists to create a resource to educate patients. There is too much misinformation, misunderstanding and blatant fraud.

        Stem cell therapy, PRP, and other biological agents are providing good results when a trained physician uses current evidence from quality research in a disciplined approach. Anything less, exposes the patient to unnecessary risk, to their finances or their health.


  48. My understanding after talking to several companies that actually harvest amniotic stem cells is that they are not considered allogenic- just like blood transfusions are not. They are not considered a drug for this reason. They MSUT be minimally processed in order to comply with this. Also the growth factors and extracellular matrix is not “added” to the compound but rather part of the amniotic tissues.

    The company that harvests have different ideas about what is best. From my research, the best companies only use cells derived from the Amnion side of the placenta (the baby side) and not the maternal side. IF a company uses the maternal side, they are more likely to quote how many cells they have per injections but this is misleading. If they can count them then the likelihood is that they are from the maternal side and thus have been washed with DMSO in order to get rid of the HLA component. This kills most of the stem cells. The injection would still include growth factors, ESM, HA, etc but not live stem cells. Companies that harvest cells from the Amnion side will not quote “numbers of cells” because they cannot test and keep the cells alive at the same time. Seems like the better companies use cells just from the baby side- live cells with no immune responses that need to be suppressed with chemicals like DMSO.


    • David, unless it’s your own blood, blood transfusions ARE allogenic – did you never hear of A, B, O types?
      For amniotic stem cells these will certainly be allogenic – most guys I know don’t have amniotic sacs from which to harvest them.


  49. This year I had Stem cells in my knees they drower blood from my arm ,it when through a process and was injected in my knees. Any one had this kind procedure? Thanks joanne


    • James that is called PRP Platelet Rich Plasma that is not stem cell therapy I had it done very painful injection and no changes in my pain


  50. Paul,
    Please correct if the information I am providing is wrong. I Goggled you. The source I found stated that:

    Paul S. Knoepfler (born April 10, 1967) is an American biologist, writer, and blogger. He is an associate professor in the Department of Cell Biology and Human Anatomy, the Genome Center, and the Comprehensive Cancer Center at the University of California, Davis School of Medicine. In 2013 Knoepfler was named one of the 50 most influential people in the stem cell field along with others such as Robert Lanza of Advanced Cell Technology as well as Nobel Laureates Shinya Yamanaka and John Gurdon. Knoepfler received a B.A. in English Literature from Reed College in 1989 and a Ph.D. in Molecular Pathology from the University of California, San Diego School of Medicine in 1998 as a Lucille P. Markey Fellow. Knoepfler’s research is focused on enhancing the safety of stem cell treatments including that of induced pluripotent stem cells and developing novel therapies to target cancers, particularly brain tumors. His lab studies the Myc oncogene and other factors that regulate stem and cancer cell chromatin including histone variant H3.3.

    This is information for individuals that are conversing on your blog to understand your background.

    Edward


  51. I am wondering if anyone has had stem cell therapy for feet. I have very painful joints in my feet especially the big toe joints, I have been told I have degenerative joint disease, I also have hypermobility of the the joints, and I have Elher’s Danlos Type III. I cannot wear shoes as the pain is so bad. The balls of my feet, arches and heels hurt and therefore makes the muscles in my feet and legs very tight. My left hip is also quite painful also due to hypermobility

    I was told that I needed the bones in my feet fused but a top orthopedic said no to the surgery, but did not know how to help. I have been on a very long journey with pain causing quite a bit of anxiety/depression as I cannot walk or exercises. I would love to hear from someone who used stem cell to repair the joints in the feet.

    Thanks,

    Cristina


    • I also have Ehler’s Danlos & hypermobility. My joints are degenerating & the ball of foot is very painful. My ankle is also degenerating & has tendonitis. It swells up like a golf ball every day. My podiatrist is suggesting amniotic injections, but I’m not sure what brand it is yet. I have read some info suggesting it is a scam. I found a clinical trial for adipose injections in my area & was considering that as well. So confused on what to do. I don’t want to end up worse off than I already am.


      • I did not have SC injections but did have several PRP treatments in my feet, toes ankles, arch, lower back, hip, leg tendons.
        Two treatments of maybe 40 injections each time. I have EDS and OA.
        First several days after felt like a car accident, but gradually much better! This was two years ago. Feet are still ok but I need a revisit with my hips and back.


  52. I have carefully read all of the comments on this blog and very much appreciate all of them. My heart goes out to all of those that have or are suffering; especially those in chronic pain. I too am considering stem cell therapy for both knees. I am 69 years old and had never had a single knee problem until this past year. X-rays and MRI’s on both show insufficient cartilage. My questions are:
    1). What is the current probability of a satisfactory/successful outcome from SC therapy?
    2) Which type of therapy offers the best chances for success?
    3). My current physician is recommending partial replacement on both knees. Which offer the best opportunity for pain-free mobile for the next ten to fifteen years? SC or surgery?
    If you have had experience with my problem I would very much appreciate your contacting me at
    beallsan@gmail.com.
    Thank you.
    Ron


    • In December, I had bone marrow removed from the back of my pelvis to inject into my knee. My knee can be so painful from one spot of bone on bone where there is a hole in the cartilage. I am 55 and have been turned down numerous times for a knee replacement. This “injury” inhibits my ability to go up and down stairs, walk at a normal pace, and walk for long distances. (I am a former runner.) I have been told that I have to wait 4-6 months before I know if it has worked. Other sites have stated 3-8 weeks for a change. I am so hopeful, but scared to death. It’s been 3 weeks and a little change. But is that cause I’m babying it? I will try to keep you updated.


      • Lifestyle can have a tremendous impact on whether stem cells will work or not. My suggestion would be a healthy diet, get a good 6-8 hours of sleep nightly, light to moderate exercise (but do not overdo it), decrease alcohol and caffeine intake, and decrease stress.


        • YES! It truly seems to be working! There is some pain, but not sharp! I had this procedure done in San Diego. I’ve checked in with my doctor and he strongly suggested PT – cause – you guessed it – I was babying my knee. I’m going to a place that uses stretch cages. Cannot find anything like that here in Chicago – where I live. I cannot believe what they have me do there! (lunges, simple squats, no weights are allowed for me nor running or jumping of any kind. Doc says that the stem cells form a “scab” and that I could still tear off that scab.) I am going up and down stairs – but all the way normal yet. I am so full of hope now – where there wasn’t any since last May.


          • Please update us asap!! I’m anxious to find out your results. I have bone on bone knees and they want to replace both.. I”m researching stem cells as a possible way out of that BUT finances are a concern…


            • I too have knee issues and am researching this procedure. Can you tell me how you researched the clinic you went to?


              • Have knee pain,but at this timecaused by Hip problem received second hip injection. may have to have hip replacement. AS far as stem cell use, my doctor suggested it possibly. I called Cleveland Clinic, and will go there for an opinion before doing any stem cell.


  53. Just a reminder to commenters, this blog and this post are not a place for clinics to recruit patients nor for patients to find clinics, which are both against the commenting policy of this blog. Discussing clinics is OK, but keeping in mind that such comments cannot be promotional of the clinic nor the opposite (e.g. calling them “frauds” by name) without having extraordinary factual evidence.
    Paul


  54. Good day to all. Has anyone had experience with Severe traumatic brain injury and stem cell treatment. I’m looking for family of the injured to speak out on any experiences.


    • I would love to hear about treatment/response for TBI as well. I have seen a trials doing autologous stem cells (from hip bone) via IV infusion and/or nasal spray. Is there any evidence for this? I was quoted $17k for one procedure… I don’t know if that is a great deal or a terrible one.

      Thanks for the input!

      Best,

      Chris


    • A friend of my husband had this done about 2 mo ago. Stem Cells from fat. Had it nasal spray, in his bad arm and IV. His arm that was affected by the stroke was sore and that improver, he seems to be getting slightly better brain function in the thinking department. We are watching because my hubby had a stroke and want to see how much improvement for the money. It cost them $10,400 and that included motel and transportation to clinic.


  55. There are NO proven treatments utilizing stem cells for ANY condition. NONE. You are all being scammed by unscrupulous providers.


    • You might want to frame your comments better next time. Thousands of bone marrow stem cell transplants are used to treat cancer and other diseases successfully every day.


      • Oh Carol.. i’d love to hear how your knees healed.. I’m bone on bone and am looking into stem cells as a possible alternative to full knee replacements surgery’s. thank you!


  56. Dear SWP,
    I would beg to differ. I have had multiple self and donor adult stem cell transplants for Stage-IV SLE. I was originally diagosed as Stage-II SLE. I tried all AMA-approved treatments prior to my stem cell transplants. The treatments either did not work or acceletated my conditon, making my SLE worse. The individual that has done my stem cell isolations published an IRB-approved clinical trial for Parkinson’s disease using the person’s own stem cells. Two months after a single transplant of their own stem cells all participants in the trial were either stable or getting better. At their 7 month and 14 month follow-ups 25% reverted and continued to decline slowly, 50% remained stable, and 25% continued to get better.

    While I am sure more work needs to be done, their PD trial results were promising enough for me to continue with my adult stem cell transplants. And I am still alive. Without the transplants I would be dead.


  57. SWP bury your head in the sand and stay a don’t believer but for me it has certainly helped. I think if you look at many of the medications and treatments today many were totted as not true. Take ulcers (bacterium Helicobacter pylori) which many said was not an infection but have now been proved wrong.


  58. I am looking for any information regarding treatment of Parkinsons. We live in Australia and the total cost for us is around the $20K USD. Anyone who has any information I would great appreciate your advice.


  59. I have had treatment for osteoarthritis in both hips with adipose derived stem cells in April and September of 2016, one procedure hurt like hell, the other in the more compromised hip less painful. There are different stem cell mixtures and viscosity which is why I had so much trouble with my first procedure. Both have proved very effective in reducing my hip pain from osteoarthritis, there are many documents on pubmed.gov if you research your condition and the viability of the procedure working for you. I would also research the popular clinic blogs for information and subscribe to those you feel address your condition. I was talked into prolotherapy for a herniated disc at L4 which was a complete disaster with no therapeutic effect at all, it set back my recovery by 3 months. It took 3 MRI’s from my PCP to verify the inflammation was causing me more pain. I spent 2 days on ice packs to return to my pre procedure mobility.
    I am currently researching stem cell therapy for stenosis of the spine at L4. It seems one of the most challenging things to obtain is justification for the procedure the clinic presents. The answer because that’s the best treatment shouldn’t cut it for anyone, you want to know why it’s the best treatment for you, if they can’t explain that walk away.


  60. I had amniotic/placental stem cell injection into my right knee in December. It is severely arthritic and I had been told the only treatment would be knee replacement. On day TWO, my pain reduction was about 80%. It has gone from severe stabbing feeling to minor “pinch” once in a while. I also have torn ACL in that knee, and know that will never heal. But I am thrilled with the outcome. I paid $4000 at a chiropractic clinic for that joint.
    In January, I partially tore the quad tendon in my left knee (which also has arthritis). I was told this is a 6 month recovery period. So I had that tendon injected with stem cells (at my orthopedist, cost $1050, didn’t know he did this procedure before I had the first knee injection). Less than 3 months later, I am at the stage where I can walk 1.5 to 2 miles per day pretty comfortably.


    • So glad to hear about your success! May I ask your age? I was turned down for a knee replacement because I was too young! I’m 55! I had bone marrow stem cell for a hole in my cartilege on my right knee. It is month 4 for me (I was told 6 months before I knew if it worked.) I’ve had a huge improvement but am not totally pain free. I used to walk with crutches and am now walking on my own. Did my first mile this week! What kind of stem cells were used on your left knee?


  61. Has anyone had stem cell treatment for neuropathy of which I have in both lower legs and feet.
    I have read in these blogs about people not wanting knee or hip replacements. I have had both knee and hip replaced and other than a little stiff upon getting up from sitting, I get around OK. After all I am only 80 years young. I did go to 2 good Doctors in San Diego Ca One in Fallbrook and the other in Escondido..


  62. Hi, just want to share my positive experience with stem cell therapy. I tore my right hip labrum due to a severe longboard (skateboard) fall, and decided to go for stem cell therapy in Korea before even thinking about arthroscopic surgery. It was adipose stem cell (through liposuction) followed by PRP straight after the stem cell injection, and 3 more PRPs about 3 days apart – so around 2 weeks in total for the whole procedure. The price was around 3500USD in total, and it was a bargain given the such a positive results. I am not completely pain free, but 80% recovered and it has stayed that way for at least a year and a half.

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