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Questions on National Academies in vitro gametogenesis (IVG) meeting sponsorship

April 26, 2023 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Research on in vitro gametogenesis or IVG is jumping ahead and such work could one day lead to new infertility treatments. In vitro gametogenesis is the process of producing gametes (sperm and eggs) from stem cells. Those powerful stem cells, called iPS cells, can be made from ordinary adult cells like skin or blood cells. […]

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Pros & cons of dead celebrity genomics

March 28, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Are there any guidelines for genomics studies of famous dead people like sequencing their genomes? It doesn’t seem like it. I remember when I first heard of the idea of trying to clone John Lennon from an old molar. Fortunately, as far as I know no one ever tried that, but it wouldn’t surprise me if

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Weekly reads: bat stem cells & viruses, Lineage Cell, He Jiankui visa

February 26, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Occasionally when I write a post there is an angry reaction to it in the blog comments, which was the case for my recent fact-check of the LifeWave X39 patches. As you can see in that post, I didn’t find convincing data to either back up the claimed stem cell connection. In my opinion, there

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Weekly reads: He Jiankui disappoints, ALS, Vor Biopharma

February 19, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

I’m sure many of you remember He Jiankui, the guy who made CRISPR babies. He ended up serving three years in jail in China. He seems to be trying for something of a comeback since his release. Were He Jiankui invitations a mistake? Some prestigious places have even invited him to give talks, which seemed

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Weekly reads: stem cell good news, bad news on sickle cell, MS, IPSCs

January 8, 2023 / Professor Paul Knoepfler, Ph.D. / 1 Comment

victoria gray family crispr sickle cell b

Let’s start with some stem cell good news on evolving approaches to treat sickle cell disease involving stem cells. Then on another related front things were more concerning. Stem cell good news on sickle cell disease, a complication Sickle Cell Disease News reports Adding Briquilimab Boosts Success of Sickle Cell Stem Cell Transplant. This is a

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2023 stem cell & regenerative medicine predictions

December 28, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Toward the end of each year, I make stem cell & regenerative medicine predictions for the coming year. It’s a fun tradition here on The Niche that goes way back. The stem cell field has changed dramatically as reflected in each year’s predictions. Here’s a list of past predictions with my grades of how they

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Grading my 2022 regenerative medicine predictions

December 20, 2022 / Professor Paul Knoepfler, Ph.D. / 4 Comments

It’s that time of year again when I grade my previous year’s predictions for the stem cell & regenerative medicine space. Overall, I did better than a typical year. I give the 2022 predictions an A- overall. This exercise can be kind of fun but also humbling. For example, I tend to be too optimistic

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Weekly reads: Kevin McCormack passes, HSCs & RXR, Ethics

December 18, 2022 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Kevin McCormack, Paul Knoepfler, stem cell research

Out of the blue this past week we lost Kevin McCormack of CIRM to a heart attack. When I first heard, my reaction was that can’t be, but it is. About Kevin McCormack If you aren’t familiar with him, Kevin was officially Director of Patient Advocacy at our state’s Stem Cell Agency. However, he was

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Fact-checking stem cell stroke therapy: hope but not there yet

December 13, 2022 / Professor Paul Knoepfler, Ph.D. / 9 Comments

Stem cell stroke therapy research has generated buzz over the years. The goal of today’s post is to fact-check claims about supposed stem cell stroke therapies and educate readers on where clinical research stands. There is some real hope here in the long run, but things have been greatly exaggerated at times. Some clinics are

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2nd chances after big misconduct? He Jiankui, James Wilson, others

December 8, 2022 / Professor Paul Knoepfler, Ph.D. / 3 Comments

There have been rare instances like with scientist James Wilson where researchers were involved in what I would call major misconduct but somehow managed to bounce back. In a sense, they were given second chances in part by regulators but also by other scientists or supporters. However, after extraordinary misconduct, especially contributing to the death

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